. . "St\u0159\u00ED\u017E, Ilja" . "Proz\u00E1n\u011Btliv\u00E9 cytokiny z rodiny IL-1 hraj\u00ED kl\u00ED\u010Dovou \u00FAlohu v regulaci z\u00E1n\u011Btliv\u00E9 odpov\u011Bdi a \u00FA\u010Dastn\u00ED se i \u0159ady imunopatologick\u00FDch reakc\u00ED. Aby mohly tyto cytokiny vykon\u00E1vat sv\u00E9 efektorov\u00E9 funkce, je zapot\u0159eb\u00ED proteolytick\u00E9 \u0161t\u011Bpen\u00ED jejich neaktivn\u00EDch forem - prekurzor\u016F. Tuto funkci zaji\u0161\u0165uj\u00ED cystein aspart\u00E1t-specifick\u00E9 prote\u00E1zy, zejm\u00E9na kasp\u00E1za-1 (d\u0159\u00EDve tzv. interleukin-1 konvertuj\u00EDc\u00ED enzym - ICE). Kasp\u00E1zy jsou produkov\u00E1ny bu\u0148kou jako katalyticky neaktivn\u00ED a pot\u00E9, co jsou podrobeny proteolytick\u00E9mu \u0161t\u011Bpen\u00ED, dojde k jejich aktivaci. D\u016Fle\u017Eitou roli p\u0159i aktivaci kasp\u00E1z nezbytn\u00FDch k sekreci proz\u00E1n\u011Btliv\u00FDch cytokin\u016F rodiny IL-1 hraj\u00ED molekuly multiproteinov\u00E9ho komplexu, naz\u00FDvan\u00E9ho inflamasom. Inhibitory kasp\u00E1z p\u0159edstavuj\u00ED atraktivn\u00ED n\u00E1stroj z\u00E1sahu u protiz\u00E1n\u011Btliv\u00E9 l\u00E9\u010Dby a z\u00E1rove\u0148 alternativu k sou\u010Dasn\u00E9 strategii blokov\u00E1n\u00ED IL-1 pomoc\u00ED rekombinantn\u00EDho solubiln\u00EDho IL-1RA, anakinry." . "P(2B06154)" . . "IL-1; IL-18; IL-33; caspases; inflammation"@en . . "2"^^ . . . . "2"^^ . "Alergie" . "3" . "RIV/00023001:_____/08:00002754" . "4"^^ . "Modulation of the overproduction of IL-1 and related cytokines"@en . . . "385668" . "10" . "RIV/00023001:_____/08:00002754!RIV12-MSM-00023001" . "Ovlivn\u011Bn\u00ED nadprodukce IL-1 a p\u0159\u00EDbuzn\u00FDch cytokin\u016F"@cs . . . "1212-3536" . "Pro-inflammatory cytokines of IL-1 family play a key role in the regulation of immune response and are involved in numerous immunopathological reactions. Proteolytic cleavage od non-active is required to perform their affectors functions. The proteolytic cleavage is ensured by cystein aspartate-specific proteases, particularly by caspase-1 (interleukin-1 converting enzyme). Caspases are produced by cell catalytically non-active and later they are proteolyticly cleaved and in this manner activated. For the activation of caspases required for the release of pro-inflammatory cytokines of IL-1 family the molecules of multiprotein complex called inflammasome are important. Caspase inhibitors represent potentially attractive tool ot the anti-inflammatory therapy and an alternative to current strategy to block IL-1 with recombinant IL-1RA, anakinra."@en . "Ovlivn\u011Bn\u00ED nadprodukce IL-1 a p\u0159\u00EDbuzn\u00FDch cytokin\u016F"@cs . . "CZ - \u010Cesk\u00E1 republika" . "Brabcov\u00E1, Eva" . "[C883750659C7]" . "Ovlivn\u011Bn\u00ED nadprodukce IL-1 a p\u0159\u00EDbuzn\u00FDch cytokin\u016F" . . . "Modulation of the overproduction of IL-1 and related cytokines"@en . . "Ovlivn\u011Bn\u00ED nadprodukce IL-1 a p\u0159\u00EDbuzn\u00FDch cytokin\u016F" . . . . "Proz\u00E1n\u011Btliv\u00E9 cytokiny z rodiny IL-1 hraj\u00ED kl\u00ED\u010Dovou \u00FAlohu v regulaci z\u00E1n\u011Btliv\u00E9 odpov\u011Bdi a \u00FA\u010Dastn\u00ED se i \u0159ady imunopatologick\u00FDch reakc\u00ED. Aby mohly tyto cytokiny vykon\u00E1vat sv\u00E9 efektorov\u00E9 funkce, je zapot\u0159eb\u00ED proteolytick\u00E9 \u0161t\u011Bpen\u00ED jejich neaktivn\u00EDch forem - prekurzor\u016F. Tuto funkci zaji\u0161\u0165uj\u00ED cystein aspart\u00E1t-specifick\u00E9 prote\u00E1zy, zejm\u00E9na kasp\u00E1za-1 (d\u0159\u00EDve tzv. interleukin-1 konvertuj\u00EDc\u00ED enzym - ICE). Kasp\u00E1zy jsou produkov\u00E1ny bu\u0148kou jako katalyticky neaktivn\u00ED a pot\u00E9, co jsou podrobeny proteolytick\u00E9mu \u0161t\u011Bpen\u00ED, dojde k jejich aktivaci. D\u016Fle\u017Eitou roli p\u0159i aktivaci kasp\u00E1z nezbytn\u00FDch k sekreci proz\u00E1n\u011Btliv\u00FDch cytokin\u016F rodiny IL-1 hraj\u00ED molekuly multiproteinov\u00E9ho komplexu, naz\u00FDvan\u00E9ho inflamasom. Inhibitory kasp\u00E1z p\u0159edstavuj\u00ED atraktivn\u00ED n\u00E1stroj z\u00E1sahu u protiz\u00E1n\u011Btliv\u00E9 l\u00E9\u010Dby a z\u00E1rove\u0148 alternativu k sou\u010Dasn\u00E9 strategii blokov\u00E1n\u00ED IL-1 pomoc\u00ED rekombinantn\u00EDho solubiln\u00EDho IL-1RA, anakinry."@cs . "http://www.tigis.cz/casopisy/pro-lekare/alergie/itemlist/category/242-c-3-2008.html" .