"Petr\u00E1\u0161ek, Jan" . . "Brabcov\u00E1, Irena" . . "Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients."@en . . . "Haplotypov\u00E1 struktura AMCB1/MDR1 genu modifikuje riziko akutn\u00ED rejekce \u0161t\u011Bpu u p\u0159\u00EDjemc\u016F transplantovan\u00E9 ledviny."@cs . "RIV/00023001:_____/08:00001846" . "[97C883DD5D4D]" . "Bioavailability of tacrolimus (Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes, which have been suggested to influence acute rejection and pharmacokinetics in renal transplantation. We aimed to study these associations in haplotype models in kohort of 832 renal transplant recipients. Acute rejection was predicted by human leukocyte antigen-DR mismatches, delayed graft function, age at renal transplantation and by the [ABCB1 +1236C; +2677G; +3435T] haplotype. ABCB1 haplotypes modify the risk of acute rejection, suggesting that ABCB1 allelic arrangement is a stronger regulator of P-glycoprotein activity than single polymorphisms. The risk of acute rejection determined by ABCB1 is independent of pharmacokinetic parameters. CYP3A haplotypes control the bioavailability of Tac, but do not modify the risk of acute rejection." . "Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients." . "9" . "Haplotypov\u00E1 struktura AMCB1/MDR1 genu modifikuje riziko akutn\u00ED rejekce \u0161t\u011Bpu u p\u0159\u00EDjemc\u016F transplantovan\u00E9 ledviny."@cs . "RIV/00023001:_____/08:00001846!RIV09-MZ0-00023001" . . "cyclosporine; cytochrome P450; haplotypes; renal transplantation; P-glycoprotein; pharmacogenetics; single nucleotide polymorphism; tacrolimus."@en . . "Biologick\u00E1 dostupnost takrolimu a cyklosporinu A je determinov\u00E1na cytochromem P450IIIA a glykoproteinem-P, kter\u00E9 jsou k\u00F3dov\u00E1ny CYP3A4/CYP3A5 a ABCB1 geny. Bylo prok\u00E1z\u00E1no, \u017Ee tyto geny ovliv\u0148uj\u00ED biologickou dostupnost imunosupresiv a akutn\u00ED rejekci u pacient\u016F po transplantaci ledviny. Haplotypovou anal\u00FDzou provedenou na souboru 832 pacient\u016F jsme prok\u00E1zali, \u017Ee akutn\u00ED rejekce byla predikov\u00E1na neshodou v lokusu HLA-DR, opo\u017Ed\u011Bn\u00FDm rozvojem funkce \u0161t\u011Bpu, v\u011Bkem p\u0159\u00EDjemce v dob\u011B transplantace a tak\u00E9 [ABCB1 +1236C; +2677G; +3435T] haplotypem. Z toho vypl\u00FDv\u00E1, \u017Ee ABCB1 hyplotypy modifikuj\u00ED riziko akutn\u00ED rejekce nez\u00E1visle na farmakokinetick\u00FDch parametrech. CYP3A haplotypy ovliv\u0148uj\u00ED farmakokinetick\u00E9 parametry takrolimu , ale nemaj\u00ED vztah k riziku akutn\u00ED rejekce."@cs . "6"^^ . . . . . . . "0041-1337" . "6"^^ . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Novotn\u00E1, Eva" . "Bioavailability of tacrolimus (Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes, which have been suggested to influence acute rejection and pharmacokinetics in renal transplantation. We aimed to study these associations in haplotype models in kohort of 832 renal transplant recipients. Acute rejection was predicted by human leukocyte antigen-DR mismatches, delayed graft function, age at renal transplantation and by the [ABCB1 +1236C; +2677G; +3435T] haplotype. ABCB1 haplotypes modify the risk of acute rejection, suggesting that ABCB1 allelic arrangement is a stronger regulator of P-glycoprotein activity than single polymorphisms. The risk of acute rejection determined by ABCB1 is independent of pharmacokinetic parameters. CYP3A haplotypes control the bioavailability of Tac, but do not modify the risk of acute rejection."@en . "H\u0159ibov\u00E1, Petra" . . . . "86" . "8"^^ . "Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients." . . . . . . . . . "Band\u00FAr, \u0160t\u011Bp\u00E1n" . "000260945600009" . . . "P(NR8816), Z(MZ0IKEM2005)" . "Viklick\u00FD, Ond\u0159ej" . "Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients."@en . "Transplantation" . "369798" .