"Arterial allografts are used nowadays as a modality in the treatment of vascular prosthesis infections. Prolonged administration of immunosuppressive drugs seemed to be essential for long time patency rates of alloarterial vascular reconstructions. Nevertheless, the use of immunosuppressives if there exists an acute infection is controversial. The experimental work described herein studied effects of a delayed low-dose FK 506 administration on the development of acute rejection changes 30 days after aortal transplantation in rats. The response of the recipient's immune system to aortal wall antigens of the donor in the field of no immunosuppression resulted in an intimal proliferation and its infiltration by immunocompetent cells of the recipient, necrosis of medial smooth muscle cells, including deposition of immunoglobulines, and a massive adventitial infiltration of CD4 and CD8 positive cells. On the other hand, all the principal histological signs of rejection listed above were suppressed by"@en . "Arterial allografts are used nowadays as a modality in the treatment of vascular prosthesis infections. Prolonged administration of immunosuppressive drugs seemed to be essential for long time patency rates of alloarterial vascular reconstructions. Nevertheless, the use of immunosuppressives if there exists an acute infection is controversial. The experimental work described herein studied effects of a delayed low-dose FK 506 administration on the development of acute rejection changes 30 days after aortal transplantation in rats. The response of the recipient's immune system to aortal wall antigens of the donor in the field of no immunosuppression resulted in an intimal proliferation and its infiltration by immunocompetent cells of the recipient, necrosis of medial smooth muscle cells, including deposition of immunoglobulines, and a massive adventitial infiltration of CD4 and CD8 positive cells. On the other hand, all the principal histological signs of rejection listed above were suppressed by" . . . "Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats" . "RIV/00023001:_____/07:00000798" . "Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats"@en . "3"^^ . "[FC1219B32602]" . . . "Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats"@en . "416111" . "371-380" . "aort\u00E1ln\u00ED \u0161t\u011Bpy, FK 506, potkany, transplantace"@cs . "Transplant international" . "Matia, Ivan" . . . . "3"^^ . "4" . . . "Lodererov\u00E1, Alena" . "20" . "RIV/00023001:_____/07:00000798!RIV08-MZ0-00023001" . "Opo\u017Ed\u011Bn\u00E9 pod\u00E1v\u00E1n\u00ED FK 506 je dostate\u010Dn\u00E9 k potla\u010Den\u00ED akutn\u00EDch rejek\u010Dn\u00EDch zm\u011Bn po transplantaci aorty u potkan\u016F."@cs . . "0934-0874" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats" . "P(NR7965)" . "10"^^ . . . . . . . "aortal grafts; FK 506; rats; transplantation"@en . "Adamec, Milo\u0161" . "Opo\u017Ed\u011Bn\u00E9 pod\u00E1v\u00E1n\u00ED FK 506 je dostate\u010Dn\u00E9 k potla\u010Den\u00ED akutn\u00EDch rejek\u010Dn\u00EDch zm\u011Bn po transplantaci aorty u potkan\u016F."@cs . .