"Petr\u00E1\u0161ek, Jan" . "Z(MZ0IKEM2005)" . "RIV/00023001:_____/07:00000793" . . . . "Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation" . "Funk\u010Dn\u00ED polymorfizmy v genech Th1 a Th2 z\u00E1n\u011Btliv\u00E9 odpov\u011Bdi mohou ovliv\u0148ovat osud transplantovan\u00E9 ledviny. Tento z\u00E1v\u011Br v\u0161ak nebyl potvrzen a proto tato studie sledovala efekt polymorfizm\u016F ve v\u011Bt\u0161\u00ED skupin\u011B p\u0159\u00EDjemc\u016F transplantovan\u00E9 ledviny. Vliv sledovan\u00FDch polymorfizm\u016F na v\u00FDskyt AR, SR, CAN a p\u0159e\u017Eit\u00ED \u0161t\u011Bpu byl analyzov\u00E1n jedno - lokusovou i haplotypovou metodou. Na rozd\u00EDl od n\u011Bkter\u00FDch star\u0161\u00EDch alelick\u00FDch asocia\u010Dn\u00EDch studi\u00ED nebyla nalezena \u017E\u00E1dn\u00E1 asociace mezi sledovan\u00FDmi polymorfizmy a osudem transplantovan\u00E9 ledviny. Tento v\u00FDsledek poukazuje na nezbytnost dal\u0161\u00EDch precizn\u00EDch v\u00FDzkum\u016F p\u0159ipraven\u00FDch na z\u00E1klad\u011B v sou\u010Dasnosti p\u0159ij\u00EDman\u00FDch norem pro alelick\u00E9 asocia\u010Dn\u00ED studie."@cs . "8" . "RIV/00023001:_____/07:00000793!RIV08-MZ0-00023001" . "7"^^ . . "Barto\u0161ov\u00E1, Kate\u0159ina" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "7"^^ . "Viklick\u00FD, Ond\u0159ej" . . "Genov\u00E1 variabilita hlavn\u00EDch medi\u00E1tor\u016F z\u00E1n\u011Btu nem\u00E1 vliv na osud transplantovan\u00E9 ledviny"@cs . "L\u00E1cha, Ji\u0159\u00ED" . . "cytokines; gene polymorphisms; chronic allograft nephropathy; acute rejection; graft function"@en . . . . "84" . . "0041-1337" . . . "Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation" . . . "Brabcov\u00E1, Irena" . "Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation"@en . . "H\u0159ibov\u00E1, Petra" . "1037-1044" . . "Functionally relevant polymorphisms in genes of the Th1 and Th2-inflammatory pathway influence the outcome of kidney transplantation. Because these findings have not been validated, we sought confirmatory evidence of these associations in a larger group of renal transplant recipients.The effects of these polymorphisms on the incidence of AR, SR, CAN and graft survival were analyzed in single locus and haplotype models. In contrast to previous allelic association studies, neither of the polymorphisms has been associated with the outcome of kidney. Our findings reinforce the need for more rigorous research compliant with the currently accepted standards for polymorphism-disease association studies." . . . "[9043A1CCE0B8]" . . "Transplantation" . . "8"^^ . "423142" . "Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation"@en . . "Genov\u00E1 variabilita hlavn\u00EDch medi\u00E1tor\u016F z\u00E1n\u011Btu nem\u00E1 vliv na osud transplantovan\u00E9 ledviny"@cs . . "Hyklov\u00E1, Kate\u0159ina" . "Functionally relevant polymorphisms in genes of the Th1 and Th2-inflammatory pathway influence the outcome of kidney transplantation. Because these findings have not been validated, we sought confirmatory evidence of these associations in a larger group of renal transplant recipients.The effects of these polymorphisms on the incidence of AR, SR, CAN and graft survival were analyzed in single locus and haplotype models. In contrast to previous allelic association studies, neither of the polymorphisms has been associated with the outcome of kidney. Our findings reinforce the need for more rigorous research compliant with the currently accepted standards for polymorphism-disease association studies."@en . .