"RIV/00023001:_____/07:00000737!RIV08-MZ0-00023001" . "Poledne, Rudolf" . "3"^^ . "CZ - \u010Cesk\u00E1 republika" . . "Introduction: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body s energy balance. We have analyzed the association of ghrelin variants with body weight changes after dietary/exercise intervention in healthy overweight females. Methods: Ghrelin variants Arg51 > Gln, Leu72 > Met and Gln90 > Leu were analyzed by PCR-RFLP in 80 overweight (BMI 31.1 +/- 3.0 kg/m2) females aged 25-55 years. Development of body weight and plasma lipids were analyzed in subgroups divided according to ghrelin genotypes. Results: Carriers of the Met72Met genotype were resistant to dietary/exercise intervention. They lost 1.5 kg compared to Leu72 carriers (5.3 kg). Other variants had no effect on body weight changes. Plasma lipids were not changed significantly between subgroups divided according to ghrelin variants. Conclusions: Common variants in ghrelin may have an effect on changes of body weight after behavior" . "\u00DAvod: Ghrelin je endogenn\u00ED hormon exprimovan\u00FD p\u0159ev\u00E1\u017En\u011B v \u017Ealudku. Ghrelin \u0159\u00EDd\u00ED sekreci r\u016Fstov\u00FDch hormon\u016F a ovliv\u0148uje i energetickou bilanci organismu. Hodnotili jsme asociaci mezi variantami genu pro ghrelin a zm\u011Bnami t\u011Blesn\u00E9 hmotnosti po \u00FAprav\u011B stravy/po fyzick\u00E9 z\u00E1t\u011B\u017Eov\u00E9 intervenci u zdrav\u00FDch \u017Een s nadv\u00E1hou. Metody: Varianty genu pro ghrelin Arg51 > Gln, Leu72 > Met a Gln90 > Leu byly analyzov\u00E1ny technikou PCR-RFLP u 80 \u017Een s nadv\u00E1hou (BMI 31,1 +/- 3,0 kg/m2) ve v\u011Bku 25-55 let. Zm\u011Bny t\u011Blesn\u00E9 hmotnosti a koncentrac\u00ED plazmatick\u00FDch lipid\u016F byly analyzov\u00E1ny v podskupin\u00E1ch podle genotyp\u016F pro ghrelin. V\u00FDsledky: Nositel\u00E9 varianty Met72Met vykazovali rezistenci v\u016F\u010Di \u00FAprav\u011B stravy/fyzicky z\u00E1t\u011B\u017Eov\u00E9 intervenci. Jejich t\u011Blesn\u00E1 hmotnost se sn\u00ED\u017Eila o 1,5 kg ve srovn\u00E1n\u00ED s nositeli varianty Leu72 (5,3 kg). Ostatn\u00ED varianty na zm\u011Bny t\u011Blesn\u00E9 hmotnosti vliv nem\u011Bly. Hodnoty plazmatick\u00FDch lipid\u016F u podskupin rozd\u011Blen\u00FDch podle variant genu pro ghrelin se statisticky v\u00FDznamn\u011B nezm\u011Bnily. Z\u00E1v\u011Bry: B\u011B\u017En\u00E9"@cs . "418935" . "Effect of ghrelin variants on weight loss after dietary/excercise interventions"@en . . . "Vliv variant genu pro ghrelin na \u00FAbytek t\u011Blesn\u00E9 hmotnosti po \u00FAprav\u011B stravy/po z\u00E1t\u011B\u017Eov\u00E9 intervenci"@cs . "P(NR8489)" . . "Introduction: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body s energy balance. We have analyzed the association of ghrelin variants with body weight changes after dietary/exercise intervention in healthy overweight females. Methods: Ghrelin variants Arg51 > Gln, Leu72 > Met and Gln90 > Leu were analyzed by PCR-RFLP in 80 overweight (BMI 31.1 +/- 3.0 kg/m2) females aged 25-55 years. Development of body weight and plasma lipids were analyzed in subgroups divided according to ghrelin genotypes. Results: Carriers of the Met72Met genotype were resistant to dietary/exercise intervention. They lost 1.5 kg compared to Leu72 carriers (5.3 kg). Other variants had no effect on body weight changes. Plasma lipids were not changed significantly between subgroups divided according to ghrelin variants. Conclusions: Common variants in ghrelin may have an effect on changes of body weight after behavior"@en . "49" . "Effect of ghrelin variants on weight loss after dietary/excercise interventions"@en . . . . . . "ghrelin; genetic polymorphism; body weight; diet; exercise"@en . . "3"^^ . . "[D4320A35FDB8]" . . . "Effect of ghrelin variants on weight loss after dietary/excercise interventions" . . "213-215" . . "RIV/00023001:_____/07:00000737" . . . "Effect of ghrelin variants on weight loss after dietary/excercise interventions" . "Such\u00E1nek, Pavel" . "0010-8650" . "3"^^ . "Vliv variant genu pro ghrelin na \u00FAbytek t\u011Blesn\u00E9 hmotnosti po \u00FAprav\u011B stravy/po z\u00E1t\u011B\u017Eov\u00E9 intervenci"@cs . . "Cor et Vasa" . "6" . "Hub\u00E1\u010Dek, Jaroslav" . .