. "[633519D7E1A8]" . "Kopkan, Libor" . . . . "N" . . "Navar, G." . "Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats" . "Intenzivn\u011Bj\u0161\u00ED tvorba superoxid\u016F ovliv\u0148uje u krys s hypertenz\u00ED indukovanou ANG-II funkci ledvin"@cs . "RIV/00023001:_____/06:00001337!RIV08-MZ0-00023001" . "Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats" . "Majid, D. S. A." . . "0363-6127" . "This study was performed to examine the role of superoxide formation in the regulation of renal hemodynamic and excretory function and to assess its contribution in the pathogenesis of ANG II-dependent hypertension. Renal responses to acute intra-arterial infusion of the O2(-) scavenger tempol (50 microg x min(-1) x 100 g body wt(-1)) with or without catalase (1,500 U x min(-1) x 100 g(-1); both native and polyethylene glycol-catalase), which reduces H2O2, were evaluated in anesthetized male Sprague-Dawley rats treated chronically with ANG II (65 ng/min) for 2 wk and compared with nontreated control rats. In ANG II-treated hypertensive rats, tempol caused increases in medullary (13 +/- 2%), cortical (5 +/- 2%), and total renal blood flow (9 +/- 2%) without altering systemic arterial pressure. There were also increases in glomerular filtration rate (9 +/- 2%), urine flow (17 +/- 4%), and sodium excretion (26 +/- 5%). However, tempol infusion in nontreated normotensive rats did not cause significant cha"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Castillo, L." . . "superoxide; angiotensin II"@en . "American Journal of Physiology-Renal Physiology" . . "F80-F86" . "4"^^ . "Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats"@en . "1"^^ . . "Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats"@en . "RIV/00023001:_____/06:00001337" . "7"^^ . . "This study was performed to examine the role of superoxide formation in the regulation of renal hemodynamic and excretory function and to assess its contribution in the pathogenesis of ANG II-dependent hypertension. Renal responses to acute intra-arterial infusion of the O2(-) scavenger tempol (50 microg x min(-1) x 100 g body wt(-1)) with or without catalase (1,500 U x min(-1) x 100 g(-1); both native and polyethylene glycol-catalase), which reduces H2O2, were evaluated in anesthetized male Sprague-Dawley rats treated chronically with ANG II (65 ng/min) for 2 wk and compared with nontreated control rats. In ANG II-treated hypertensive rats, tempol caused increases in medullary (13 +/- 2%), cortical (5 +/- 2%), and total renal blood flow (9 +/- 2%) without altering systemic arterial pressure. There were also increases in glomerular filtration rate (9 +/- 2%), urine flow (17 +/- 4%), and sodium excretion (26 +/- 5%). However, tempol infusion in nontreated normotensive rats did not cause significant cha" . "474227" . . "Intenzivn\u011Bj\u0161\u00ED tvorba superoxid\u016F ovliv\u0148uje u krys s hypertenz\u00ED indukovanou ANG-II funkci ledvin"@cs . "290" . "tvorba superoxidu, patogeneze ANG II-dependentn\u00ED hypertenze"@cs . . "1" .