"Pracovi\u0161t\u011B se v\u011Bnuje anal\u00FDze biolog. v\u00FDznamn\u00FDch molekul\u00E1rn\u00EDch komplex\u016F struktury chromoz\u00F3m\u016F, p\u0159edev\u0161\u00EDm jejich nepostradateln\u00FDch koncov\u00FDch dom\u00E9n telomer. Proveden objev telomer\u00E1zy (enzymov\u00E9ho komplexu syntetizuj\u00EDc\u00EDho telomery) v rostlinn\u00FDch bu\u0148k\u00E1ch."@cs . . . " chromosome architecture" . " chromatin structure" . "45"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=VS97032"^^ . "Anal\u00FDza biologicky v\u00FDznamn\u00FDch molekul\u00E1rn\u00EDch komplex\u016F" . "45"^^ . . "biomacromolecules; nucleoprotein complexes; chromatin structure; chromosome architecture; telomeres"@en . "biomacromolecules" . . . "0"^^ . . . "C\u00EDlem projektu je vytvo\u0159en\u00ED laborato\u0159e zam\u011B\u0159en\u00E9 na studium funk\u010Dn\u011B v\u00FDznamn\u00FDch komplex\u016F biomakromolekul, zejm. nukleov\u00FDch kyselin a protein\u016F, kter\u00E9 tvo\u0159\u00ED tzv. architekturu genomu (telomery, centromery, bloky heterochromatinu, komplexy jadern\u00E9 matrix, nukloz\u00F3my). Metabolismus genetick\u00E9ho materi\u00E1lu (replikace, transkripce, rekombinace) prob\u00EDh\u00E1 na t\u011Bchto komplexech a proto v\u00FDrazn\u011B z\u00E1vis\u00ED na jejich vlastnostech. Studium genetick\u00E9 informace v jadern\u00E9m kontextu bude osou v\u00FDchovy na\u0161ich postgradu\u00E1ln\u00EDch student\u016FV n\u00E1sleduj\u00EDc\u00EDch \u010Dty\u0159ech letech budou charakterizov\u00E1ny nukleoproteinov\u00E9 komplexy tvo\u0159\u00EDc\u00ED nepostradateln\u00E9 funk\u010Dn\u00ED elementy eukaryontn\u00EDch chromoz\u00F3m\u016F - telomery." . "0"^^ . "1"^^ . . . "The aim of the project is to build a laboratory focused on the study of functionally important complexes of biomacromolecules, namely those of nucleic acids and proteins, which form so called genome architecture (telomeres, centromeres, A study of the genetic heterochromatin blocks, complexes of nuclear matrix, nucleosomes). Metabolism of genetic material (replication, transcription, recombination) proceeds at these complexes and is, therefore, significantly affected by their properties. information in its nuclear context will determine the basis of education of our postgraduate students. During the next four years, the nucleoprotein complexes will be characterised, which form indispensable functional elements of eukaryotic chromosomes - the telomeres."@en . . "VS97032" . . . . . " nucleoprotein complexes" . . "Analysis of biologically important molecular complexes"@en .