"VS96097" . . . " case-control study" . . . "An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes. A %22case-control%22 study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common %22civilization%22 diseases, as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods. It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied."@en . "85"^^ . . . "85"^^ . . "0"^^ . . . . "0"^^ . " candidate gene approach" . . . "1"^^ . "Molecular pathophysiology of selected multigenic related to civilization diseases"@en . "genetics of multigenic diseases" . "Molekul\u00E1rn\u00ED patofyziologie vybran\u00FDch %22civiliza\u010Dn\u00EDch%22, multigenn\u011B podm\u00EDn\u011Bn\u00FDch chorob" . . "Byla zalo\u017Eena molekul\u00E1rn\u011B-biologick\u00E1 laborato\u0159 studuj\u00EDc\u00ED genetiku multifaktori\u00E1ln\u00EDch civiliza\u010Dn\u00EDch nemoc\u00ED (esenci\u00E1ln\u00ED hypertenze, ischemick\u00E9 choroby srde\u010Dn\u00ED, atopi\u00ED, pozdn\u00EDch n\u00E1sledk\u016F diabetu 2, invazivn\u00EDho r\u016Fstu tumor\u016F aj.)."@cs . "http://www.isvav.cz/projectDetail.do?rowId=VS96097"^^ . . "genetics of multigenic diseases, candidate gene approach, case-control study, intermediate phenotype"@en . . "Provedeme rozs\u00E1hlou studii asociac\u00ED mezi alelick\u00FDmi variantami vybran\u00FDch polymorfn\u00EDch gen\u016F s n\u011Bkolika multigenn\u011B podm\u00EDn\u011Bn\u00FDmi v populaci roz\u0161\u00ED\u0159en\u00FDmi chorobami, pop\u0159. jejich intermedi\u00E1rn\u00EDmi znaky. Strategi\u00ED v\u00FDzkumu je popula\u010Dn\u00ED \u0161et\u0159en\u00ED genetick\u00E9ho polymorfismu vybran\u00FDch kandid\u00E1tn\u00EDch gen\u016F pro patogenesu hypertensn\u00EDch a ischemick\u00FDch nemoc\u00ED, insulin non dependentn\u00EDho diabetes mellitus, atopick\u00E9ho fenotypu a n\u011Bkter\u00FDch hematologick\u00FDch malignit a navazuj\u00EDc\u00ED zji\u0161\u0165ov\u00E1n\u00ED asociac\u00ED mezi dan\u00FDm (multigenn\u011B zalo\u017Een\u00FDm)znakem/stavem a alelick\u00FDmi variantami na kandid\u00E1tn\u00EDch genech pomoc\u00ED multivaria\u010Dn\u00EDch statistick\u00FDch metod." . .