. "2015-01-01+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=TA04010727"^^ . . "TA04010727" . . . . "The project is focused on the development of advanced methods and support tools for verification of donors selected for bone marrow transplants. The purpose of the novel methods and tools is to capitalize on available DNA sequence data of HLA and non-HLA genes in order to increase economical and temporal efficiency of the donor search process. The integrated methods will also provide a high level of adaptability of the bone marrow registry information system with respect to the progressive field of hematooncologie. The project primarily addresses the development of a new class of DNA-based tools, including their methods and algorithms, providing decision support during the verification of a potential donor. Two fundamental problems are solved in the development: organisation and interpretation of mass amounts of data (big data) and optimisation of processes built on top of mass amounts of data. Project phases proceed step-by-step from data organisational concepts, optimisation definitions, algorithm design, and testing in the existing informational system and laboratory settings. Throughout, the project also deals with development of automated tools for sharing of data and finding with the international community."@en . "Optimalizace (ekonomick\u00E9 a \u010Dasov\u00E9) efektivnosti verifika\u010Dn\u00EDch proces\u016F vyhled\u00E1v\u00E1n\u00ED d\u00E1rce kostn\u00ED d\u0159en\u011B" . "Projekt je zam\u011B\u0159en na v\u00FDvoj pokro\u010Dil\u00FDch metod a n\u00E1stroj\u016F podpory p\u0159i verifikaci d\u00E1rce vybran\u00E9ho pro transplantaci kostn\u00ED d\u0159en\u011B. C\u00EDlem nov\u011B vyvinut\u00FDch metod a n\u00E1stroj\u016F je zv\u00FD\u0161en\u00ED ekonomick\u00E9 a \u010Dasov\u00E9 efektivnosti p\u0159i vyhled\u00E1v\u00E1n\u00ED vhodn\u00E9ho d\u00E1rce a to vyu\u017Eit\u00EDm p\u0159\u00EDm\u00FDch z\u00E1znam\u016F DNA sekvenc\u00ED HLA (Human Leukocyte Antigen) i non-HLA charakteristik. Integrovan\u00E9 metody budou t\u00E9\u017E zaji\u0161\u0165ovat adaptibilitu syst\u00E9mu registru d\u00E1rc\u016F kostn\u00ED d\u0159en\u011B v\u016F\u010Di vysoce progresivn\u00ED oblasti hematoonkologie. Hlavn\u00ED n\u00E1pln\u00ED projektu je v\u00FDvoj nov\u00E9 t\u0159\u00EDdy DNA-based n\u00E1stroj\u016F, v\u010Detn\u011B metod a algoritm\u016F, slou\u017E\u00EDc\u00EDch pro podporu rozhodov\u00E1n\u00ED odborn\u00EDk\u016F b\u011Bhem verifikace potenci\u00E1ln\u011B vhodn\u00E9ho d\u00E1rce. V\u00FDvoj \u0159e\u0161\u00ED problematiku s hlediska organizace a interpretace velk\u00E9ho po\u010Dtu dat (big data) a s hlediska optimalizace proces\u016F nad velk\u00FDm po\u010Dtem dat. Etapy projektu se postupn\u011B zam\u011B\u0159uj\u00ED na koncepty datov\u00E9 organizace, definice optimalizace, n\u00E1vrh algoritm\u016F a testov\u00E1n\u00ED algoritm\u016F v laboratorn\u00EDm prost\u0159ed\u00ED a ve st\u00E1vaj\u00EDc\u00EDm informa\u010Dn\u00EDm syst\u00E9mu. V celkov\u00E9m pr\u016Fb\u011Bhu projektu se t\u00E9\u017E \u0159e\u0161\u00ED n\u00E1stroje pro automatizovan\u00E9 propojen\u00ED DNA dat a poznatk\u016F v mezin\u00E1rodn\u00ED spole\u010Dnosti." . . . . . . . "Efficiency (economic and time) optimization of the bone marrow donor verification process"@en . "optimization of DNA based search algorithm- verification process- big data- DNA sequencing- data exchange"@en . "2015-05-05+02:00"^^ . . "1"^^ . . . "0"^^ . . . "0"^^ . . "0"^^ . . "2017-12-31+01:00"^^ . . "0"^^ .