. . . " Huntington disease" . "2014-12-31+01:00"^^ . "0"^^ . "Projekt lze definovat jako soust\u0159ed\u011Bn\u00E9 \u00FAsil\u00ED aplikovan\u00E9ho v\u00FDzkumu k vytvo\u0159en\u00ED jedine\u010Dn\u00FDch biomedic\u00EDnsk\u00FDch model\u016F z\u00E1va\u017En\u00FDch lidsk\u00FDch onemocn\u011Bn\u00ED: traumatick\u00E9ho po\u0161kozen\u00ED m\u00EDchy a Huntingtonovy choroby. T\u011Bsn\u00E1 spolupr\u00E1ce v\u00FDzkumn\u00E9ho t\u00FDmu a soukrom\u00E9 firmy umo\u017En\u00ED co nejv\u010Dasn\u011Bj\u0161\u00ED aplikaci t\u011Bchto model\u016F ve farmakokinetick\u00E9m testov\u00E1n\u00ED a jejich v\u00FDznamn\u00E9 ekonomick\u00E9 zhodnocen\u00ED. Dosa\u017Een\u00ED tohoto c\u00EDle je re\u00E1ln\u00E9 v pr\u016Fb\u011Bhu \u010Dty\u0159 let \u0159e\u0161en\u00ED. Oba partne\u0159i (U\u017DFG a BioTest) budou usilovat o co nejv\u010Dasn\u011Bj\u0161\u00ED zaveden\u00ED obou model\u016F do pov\u011Bdom\u00ED jak v\u011Bdeck\u00FDch instituc\u00ED v Evropsk\u00E9m v\u00FDzkumn\u00E9m prostoru, tak v\u0161ech farmaceutick\u00FDch a biotechnologick\u00FDch firem orientovan\u00FDch na l\u00E9\u010Den\u00ED neurologick\u00FDch onemocn\u011Bn\u00ED." . "TA01011466" . . "1"^^ . "1"^^ . "2011-01-01+01:00"^^ . . . "12"^^ . "12"^^ . . . . . . "Miniature pig; spinal cord injury; Huntington disease; testing of new medicaments; cell therapy"@en . " spinal cord injury" . "2015-05-05+02:00"^^ . . . "Vypracov\u00E1n\u00ED biomedic\u00EDnsk\u00FDch model\u016F na miniaturn\u00EDch prasatech pro testov\u00E1n\u00ED nov\u00FDch l\u00E9\u010Debn\u00FDch postup\u016F pro traumatick\u00E9 po\u0161kozen\u00ED m\u00EDchy a neurodegenerativn\u00ED onemocn\u011Bn\u00ED" . "Biomedical model of miniature pigs for testing of new medicaments and for new treatments of traumatic spinal cord injury and neurodegenerative diseases"@en . . "The Applicant submitting the current project (BIOMEDTEST) is the Institute of Animal Physiology and Genetics of the Academy of Sciences of the Czech Republic and its essentials partner for realization of the project: BioTest Company. The main objective of the BIOMEDTEST project is to develop biomedical models of spinal cord injury and Huntington disease in miniature pigs. We want to achieve the objective by implementing the following research programs: a/ to develop a unique model of spinal cord defects in miniature pigs, b/ to discover the optimal combination of protein markers that will characterize cells intended for transplantation, to test safe application of cell therapy, to prepare the acute and transgenic models of Huntington disease via application of lentiviral vectors for mutated huntingtin. All biomedical models will be offered for practical testing of new medicaments and methods of cell therapy."@en . . . " testing of new medicaments" . "http://www.isvav.cz/projectDetail.do?rowId=TA01011466"^^ . . "2013-02-28+01:00"^^ . . . "Miniature pig" .