"http://www.isvav.cz/projectDetail.do?rowId=QJ1210041"^^ . . . "C\u00EDlem p\u0159edkl\u00E1dan\u00E9ho projektu je z\u00EDsk\u00E1n\u00ED nov\u00FDch v\u011Bdomost\u00ED a postup\u016F, aplikovan\u00FD v\u00FDzkum a v\u00FDvoj nov\u00E9ho typu vakc\u00EDny proti inkluzn\u00ED hepatitid\u011B kura dom\u00E1c\u00EDho (Gallus domesticus), je\u017E povede ke zv\u00FD\u0161en\u00ED odolnosti chov\u016F brojler\u016F, masn\u00E9ho a nosn\u00E9ho typu slepic.Jedine\u010Dnost nov\u00E9ho typu vakc\u00EDny je zalo\u017Eena na v\u00FDhodn\u00E9 kombinaci sm\u011Brovan\u00FDch biotinylovan\u00FDch protil\u00E1tek, rozezn\u00E1vaj\u00EDc\u00EDch specifick\u00E9 endocytovan\u00E9 bun\u011B\u010Dn\u00E9 receptory, a na proteinov\u00E9 f\u016Fzi antigen\u016F s tetramern\u00EDm streptavidinem. Na streptavidin budou molekul\u00E1rn\u011B geneticky p\u0159ipojeny r\u016Fzn\u00E9 antigeny tak, aby byla zachov\u00E1na schopnost streptavidinu tvo\u0159it tetrametry, kter\u00E9 v\u00E1\u017E\u00ED s vysokou afinitou biotin. V\u00FDsledkem bude komplex antigen-streptavidin-biotinylovan\u00E1 protil\u00E1tka proti povrchov\u00FDm endocytovan\u00FDm receptor\u016Fm na antigen presentuj\u00EDc\u00EDch bu\u0148k\u00E1ch (APC). D\u00EDky p\u0159\u00EDm\u00E9mu c\u00EDlen\u00ED na APC p\u0159edpokl\u00E1d\u00E1me, \u017Ee dojde k v\u00FDrazn\u00E9mu sn\u00ED\u017Een\u00ED \u00FA\u010Dinn\u00E9 d\u00E1vky ve srovn\u00E1n\u00ED s imunizac\u00ED pomoc\u00ED voln\u00E9ho antigenu a k aktivaci protektivn\u00ED T-bun\u011B\u010Dn\u00E9 imunitn\u00ED odpov\u011Bdi." . . . "vaccine; poultry; dendritic cells; inclusion body hepatitis"@en . . . "2016-12-31+01:00"^^ . . . . "2012-04-01+02:00"^^ . "New type of vaccine against chicken viral diseases"@en . "Nov\u00FD typ vakc\u00EDny pro tlumen\u00ED virov\u00FDch onemocn\u011Bn\u00ED u dr\u016Fbe\u017Ee" . "QJ1210041" . "1"^^ . . . . "3"^^ . . " poultry" . " dendritic cells" . . . "0"^^ . . . "vaccine" . . . "10"^^ . "2014-04-15+02:00"^^ . "The aim of this project is development of new vaccine against chicken inclusion body hepatitis (IBH).The originality of this vaccine is based on combination of biotin conjugated antibodies which are able to bind specific endocyting cell receptors on antigen presenting cells (APC) and on fusion of specific antigenes with streptavidin. Through direct targeting on APC we will assume the decreasing of effective dose of vaccine comparing with usual protocol of immunisation."@en . "2015-04-14+02:00"^^ . "10"^^ .