. "0"^^ . "V r\u00E1mci \u0159e\u0161en\u00ED projektu byly ur\u010Deny st\u0159edn\u00ED smrtn\u00E9 d\u00E1vky pro vybran\u00E9 toxiny a antidota, kalkulov\u00E1ny protektivn\u00ED indexy a farmakokinetika antidot pro laboratorn\u00ED mor\u010De a potkana. Poda\u0159ilo se definovat rozd\u00EDly mezi jmenovan\u00FDmi organizmy s ohledem na toxikologick\u00E9 vyu\u017Eit\u00ED. P\u0159i \u0159e\u0161en\u00ED projektu bylo oti\u0161t\u011Bno osm prac\u00ED v periodic\u00EDch s IF."@cs . "OVUOFVZ200905" . . . "1"^^ . "nerve agent" . "nerve agent, reactivators, Guinea Pig, morphology"@en . . "2011-02-28+01:00"^^ . "0"^^ . "The aim of this project is determine the physiological activity of Acetyl Choline Esterase (AChE) and detection of LD50 of inhibitors paraoxon, tabun, cyklosarine and reactivators AChE pralidoxim, obidoxim, trimedoxim, HI-6, methoxim. Next task is asses protective effectively of reactivators. Also detection of AChE activity in organs after intoxication with nerve compound and following reactivation. We will also follow up plasmatic concentration of reactivatos in plasma after i.m. administration and morphological changes in the tissues."@en . . "http://www.isvav.cz/projectDetail.do?rowId=OVUOFVZ200905"^^ . . " reactivators" . . "MOR\u010CE - P\u016Fsoben\u00ED nervov\u011B paralytick\u00FDch l\u00E1tek a reaktiv\u00E1tor\u016F acetylcholinester\u00E1zy na mor\u010De" . "2012-07-02+02:00"^^ . "2009-07-01+02:00"^^ . . " Guinea Pig" . . . . . . . "Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig"@en . . "Median lethal doses for selected toxins and antidots were assessed, pharmacokinetics and protective indexes were calculated during the project solving. The results were achieved for both laboratory guinea pig and rats. Owing to suitability for toxicological experiments, we proved differences between the two laboratory animals. The results were printed in eight papers in journals with IF."@en . . "6"^^ . "6"^^ . . "2011-12-31+01:00"^^ . "C\u00EDlem projektu je stanoven\u00ED fyziologick\u00FDch hodnot aktivity cholinester\u00E1z, ur\u010Den\u00ED LD50 inhibitor\u016F acetylcholinester\u00E1zy (AChE) - paraoxon, tabun, cyklosarin ,ur\u010Den\u00ED LD50 reaktiv\u00E1tor\u016F AChE- pralidoxim, obidoxim, trimedoxim, HI-6, methoxim acetylcholinester\u00E1zy, ur\u010Den\u00ED protektivn\u00ED \u00FA\u010Dinnosti a stanoven\u00ED aktivity cholinester\u00E1z ve vybran\u00FDch org\u00E1nech po intoxikaci nervov\u011B paralytickou l\u00E1tkou a n\u00E1sledn\u00E9 reaktivaci vybran\u00FDm reaktiv\u00E1torem AChE, d\u00E1le pak sledov\u00E1n\u00ED plazmatick\u00E9 koncentrace reaktiv\u00E1toru acetlycholinester\u00E1zy po jeho i.m. pod\u00E1n\u00ED. D\u00E1le posouzen\u00ED morfologick\u00FDch zm\u011Bn ve tk\u00E1n\u00EDch." . . .