"5"^^ . "2012-12-31+01:00"^^ . "V r\u00E1mci projektu byl navr\u017Een antidotn\u00ED prost\u0159edek pro ochranu p\u0159ed nervov\u011B paralytick\u00FDmi l\u00E1tkami (NPL), kombinuj\u00EDc\u00ED butyrylcholinesterasu (BChE) a jej\u00ED reaktiv\u00E1tor. V\u00FDstupem jsou struktury in vitro \u00FA\u010Dinn\u00FDch reaktiv\u00E1tor\u016F BChE, inhibovan\u00E9 NPL. Reaktiv\u00E1tory by m\u011Bly b\u00FDt v budoucnu podrobeny hodnocen\u00ED in vivo, aby byla zhodnocena mo\u017Enost jejich vyu\u017Eit\u00ED v antidotn\u00ED v\u00FDbav\u011B Arm\u00E1dy \u010Cesk\u00E9 republiky."@cs . "2013-06-27+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=OVUOFVZ200902"^^ . "OTRAVA - V\u00FDzkum nov\u00FDch typ\u016F antidot otrav nervov\u011B paralytick\u00FDmi l\u00E1tkami na b\u00E1zi scavenger\u016F" . " Oxime" . . " Pesticide" . " Butyrylcholinesterase" . "Organophosphorus compounds are weaponized in some countries as chemical warfare agents (sarin, tabun, VX). These compounds inhibit enzymes acetylcholinesterase and butyrylcholinesterase. As antidotes of poisonings by these compounds are often used anticholinergics (atropine, benactyzine) and cholinesterase reactivators (pralidoxime, obidoxime, HI-6). Favorable solution is using of specific enzymes (mostly cholinesterases) as scavengers, able to catch toxic organophosphorus compounds in the bloodstream before they start their toxic effect in the organism. We would like to find suitable cholinesterase reactivators, with the aim to suggest and test their combination with enzymes as pseudocatalytic bioscavenger. This combination allows increase prophylactic efficacy of administered enzyme."@en . . . "Acetylcholinesterase" . . . . " Prophylaxis" . "Novel prophylactic antidotes of nerve agent poisonings based on scavengers"@en . " Organophosphate" . "OVUOFVZ200902" . . "Organick\u00E9 slou\u010Deniny fosforu jsou ve v\u00FDzbroji n\u011Bkter\u00FDch st\u00E1t\u016F jako bojov\u00E9 chemick\u00E9 l\u00E1tky (sarin, tabun, VX. Inhibuj\u00ED v t\u011Ble enzymy acetylcholinester\u00E1zu a butyrylcholinester\u00E1zu. Jako antidota v p\u0159\u00EDpad\u011B otrav se pou\u017E\u00EDvaj\u00ED anticholinergika (atropin, benactyzin). D\u00E1le reaktiv\u00E1tory cholinester\u00E1z (pralidoxim, obidoxim, HI-6), kter\u00E9 obnovuj\u00ED (\u201Ereaktivuj\u00ED\u201C) funkci inhibovan\u00E9ho enzymu. V\u00FDhodn\u00FDm \u0159e\u0161en\u00EDm je pou\u017Eit\u00ED ur\u010Dit\u00FDch enzym\u016F (zejm\u00E9na cholinester\u00E1z) jako scavenger\u016F. Vychyt\u00E1vaj\u00ED organofosf\u00E1ty v krevn\u00EDm ob\u011Bhu je\u0161t\u011B p\u0159edt\u00EDm, ne\u017E za\u010Dnou toxicky p\u016Fsobit na organismus. Cht\u011Bli bychom se zab\u00FDvat nalezen\u00EDm vhodn\u00FDch reaktiv\u00E1tor\u016F cholinester\u00E1z, navrhnout a otestovat jejich kombinaci s enzymy ve funkci pseudokatalytick\u00E9ho scavengeru, co\u017E by umo\u017Enilo zv\u00FD\u0161it profylaktickou \u00FA\u010Dinnost pod\u00E1van\u00E9ho enzymu." . . . "2009-07-01+02:00"^^ . . " Scavenger" . . . . "Acetylcholinesterase, Butyrylcholinesterase, Nerve Agent, Organophosphate, Pesticide, Reactivator, Oxime, Scavenger, Bioscavenger, Prophylaxis, Therapy, In Vitro"@en . "2012-02-18+01:00"^^ . . "0"^^ . " Bioscavenger" . . " Reactivator" . . "The result of the project was a proposal of antidotal mean for the protection against nerve agents (NA), combining butyrylcholinesterase (BChE) and its reactivator. The outcomes of the project are structures of potent in vitro reactivators of NA agent-inhibited BChE. These substances should be in future evaluated in vivo to determine their possible use within the antidotal means in the Czech Army."@en . " Nerve Agent" . "1"^^ . . "0"^^ . . " Therapy" . "5"^^ . .