"V POV RadSpec byly hodnoceny \u00FA\u010Dinky ionizuj\u00EDc\u00EDho z\u00E1\u0159en\u00ED a nervov\u011B paralytick\u00FDch l\u00E1tek (soman, VX) na expresi aktivovan\u00FDch MAPK a p53/p21 sign\u00E1ln\u00EDch drah u potkana in vivo ve snaze naj\u00EDt radiospecifick\u00E9 biodozimetrick\u00E9 ukazatele. Z v\u00FDsledk\u016F nap\u0159. vypl\u00FDv\u00E1, \u017Ee exprese p21 v perifern\u00EDch mononukle\u00E1rn\u00EDch bu\u0148k\u00E1ch krve vykazuje d\u00E1vkov\u011B z\u00E1visl\u00FD vezstup ke 3 Gy 4 h po oz\u00E1\u0159en\u00ED a m\u016F\u017Ee nal\u00E9zt praktick\u00E9 u\u017Eit\u00ED."@cs . . . "2011-02-28+01:00"^^ . . . " Markers fosfo-p53" . . "OVUOFVZ200812" . . "Short-term and long-term nonspecific changes in organisms exposed to high and low doses of nerve agents on cellular and molecular level"@en . . . "2008-10-01+02:00"^^ . "C\u00EDlem studie je ov\u011B\u0159en\u00ED vhodnosti a perspetivy marker\u016F, jako jsou fosfo-elk-1, fosfo-atf-2, fosfo-CREB, fosfo-p53 (aktivovan\u00FD v serinu 15), na modelu krys zasa\u017Een\u00FDch nervov\u011B paralytickou l\u00E1tkou (soman) ke stanoven\u00ED jejich radiospecificity." . "0"^^ . . . "1"^^ . . "RADSPEC - Kr\u00E1tkodob\u00E9 a dlouhodob\u00E9 nespecifick\u00E9 zm\u011Bny organismu exponovan\u00E9ho vysok\u00FDm i n\u00EDzk\u00FDm d\u00E1vk\u00E1m nervov\u011B paralytick\u00FDch l\u00E1tek na bun\u011B\u010Dn\u00E9 a molekul\u00E1rn\u00ED \u00FArovni" . . "3"^^ . "0"^^ . "3"^^ . " Evaluation radiospecificity of markers" . "In RadSpec project, we compared ionizing radiation and nerve agents (soman, VX) effects on expression of activated MAPK and p53/p21 signalling pathways in rats in vivo in an attempt to find radiospecific biodozimetric markers. Among many results, p21 expression measured in peripheral mononuclear blood cells shows dose-dependent increase up to 3 Gy 4 h after irradiation and may find practical use."@en . "Rat" . . "The goal of this study is to evaluate expression of perspective biodosimetric markers, such as fosfo-elk-1, fosfo-atf-2, fosfo-CREB, fosfo-p53 (aktivated at serine 15), on the model of nervous paralytic compound (soman) intoxicated rats to investigate their radiospecificity."@en . . "2012-07-02+02:00"^^ . . . . . . "Rat, Markers fosfo-p53, Soman, Evaluation radiospecificity of markers, ELISA testing"@en . " Soman" . "http://www.isvav.cz/projectDetail.do?rowId=OVUOFVZ200812"^^ . "2011-12-31+01:00"^^ . .