"INCO BIOMED-2 (Concerted Action on Cystic Fibrosis)"@en . "0"^^ . "OK 192" . "http://www.isvav.cz/projectDetail.do?rowId=OK 192"^^ . . "1"^^ . . . "0"^^ . . . "bude dod\u00E1no ve verzi 2"@en . "0"^^ . . . . . . "INCO BIOMED-2 (Mezin\u00E1rodn\u00ED kooperativn\u00ED studie cystick\u00E9 fibr\u00F3zy)" . . . . "Oponentn\u00ED rada p\u0159ijala v\u00FDsledky \u0159e\u0161en\u00ED projektu."@cs . "Vy\u0161et\u0159en\u00ED dosud neidentifikovateln\u00FDch mutac\u00ED CFTR genu k zaji\u0161t\u011Bn\u00ED p\u0159\u00EDm\u00E9 molekul\u00E1rn\u011B genetick\u00E9 prenat\u00E1ln\u00ED diagnostiky a prevence cystick\u00E9 fibr\u00F3zy metodami multiplexn\u00ED DGGE,metodou OLA a kvantitativn\u00ED fluorescen\u010Dn\u00ED PCR. Bude proto zdokonalena multiplexn\u00ED DGGE,zavedena metoda OLA a kvantitativn\u00ED fluorescen\u010Dn\u00ED PCR na \u00FArovni oocytu, pol\u00E1rn\u00EDch t\u011Bl\u00EDsek,izolovan\u00FDch blastomer a mikrokvant bun\u011Bk plodov\u00E9 vody a placenty. P\u0159esn\u00E1 charakteristika nov\u00FDch mutac\u00ED bude prov\u00E1d\u011Bna ve spolupr\u00E1ci se zahrani\u010Dn\u00EDmi pracovi\u0161ti na p\u0159\u00EDstroji ABI 310 PRISM. Vy\u0161et\u0159en\u00ED oocyt\u016F,spermi\u00ED,pol\u00E1rn\u00EDch t\u011Bl\u00EDsek a blastomer bude rozv\u00EDjeno zaveden\u00EDm nejnov\u011Bj\u0161\u00EDch mikromanipula\u010Dn\u00EDch metod. Hlavn\u00EDm c\u00EDlem je zaveden\u00ED preimplanta\u010Dn\u00ED prenat\u00E1ln\u00ED diagnostiky mutac\u00ED CFTR genu a zdokonalen\u00ED prenat\u00E1ln\u00ED prevence cystick\u00E9 fibr\u00F3zy a z\u00E1chytu geneticky risikov\u00FDch rodin k \u010Dasn\u00E9 prevenci a l\u00E9\u010Db\u011B cystick\u00E9 fibr\u00F3zy." . . . "0"^^ . .