"http://www.isvav.cz/projectDetail.do?rowId=OK 184"^^ . . . . "Preparation of glycosylated silymarin for better solubility and targetting."@en . . "OK 184" . . . . . " glykosylace" . "Farmacie" . " silymarin" . . "0"^^ . . . . "3"^^ . "0"^^ . "3"^^ . . . "P\u0159\u00EDprava glykosylovan\u00FDch deriv\u00E1t\u016F silymarinu pro zlep\u0161en\u00ED sm\u011B\u0159ov\u00E1n\u00ED a rozpustnosti l\u00E9\u010Diva." . "1"^^ . "Farmacie, glykosylace, silymarin, hepatologie, sm\u011Brovan\u00E1 l\u00E9\u010Diva"@en . . "Projekt se zab\u00FDv\u00E1 p\u0159\u00EDpravou glykosylovan\u00FDch deriv\u00E1t\u016F silymarinu - flavolignanu izolovan\u00E9ho ze semen rostliny Ostropest\u0159ec mari\u00E1nsk\u00FD. Silymarin p\u016Fsob\u00ED jako radik\u00E1lov\u00FD scavenger a antioxidant membr\u00E1nov\u00FDch lipid\u016F. Jeho nev\u00FDhodou je mal\u00E1 rozpustnost ve vod\u011B a n\u00EDzk\u00E1 biodostupnost. Tento projekt sm\u011B\u0159uje k ostran\u011Bn\u011Bn\u00ED t\u011Bchto nev\u00FDhod t\u00EDm, \u017Ee se p\u0159iprav\u00ED glykosylovan\u00E9 deriv\u00E1ty silybinu, kter\u00E9 budou m\u00EDt vy\u0161\u0161\u00ED rozpustnost ve vod\u011B. D\u00E1le u galaktosidu se p\u0159edpokl\u00E1d\u00E1 vysok\u00E1 afinita k c\u00EDlov\u00E9 tk\u00E1ni, tj. hepatocyt\u016Fm. T\u00EDm se podstatn\u011B zv\u00FD\u0161\u00ED i biodostupnost prepar\u00E1tu. Zaveden\u00EDm alfa-glukosylov\u00E9ho zbytku do molekuly se d\u00E1le je\u0161t\u011B zv\u00FD\u0161\u00ED prostup membr\u00E1nou tenk\u00E9ho st\u0159eva." . " hepatologie" .