"Our project is focused (in accordance with the technical possibilities, numbers of patients in the Czech Republic, previous focus of our research and the individual working goals of EuGESMA) on the ed scientific problems concerning childhood AML and MDS. We will define and test a newly modified immunophenotypic diagnostic and stratification of childhood AML and MDS. We will test the potential of polychromatic flow cytometry for a new definition of molecular remission and residual disease follow-up. We will determine the role of expression quantification of WT1 gene and its isoforms in the diagnosis and follow-up of childhood AML and MDS. In vitro we will apply valproic acid as a new treatment modality in the cases of AML1/ETO-positive AML. In cases of secAL, we will search for so-far unknown genetic aberrations. We will contribute to expression profiling studies in childhood AML."@en . . "Project of the molecular characterisation of childhood acute myeloid leukaemias and myelodysplastic syndrome was successfully finalised by the publication of 4 original research publications in the international journals (Leukemia, Haematologica, Cancer Letters) moreover, one additional consortium publication in the Leukemia journal was published and other publications are prepared."@en . "0"^^ . . . "3"^^ . "0"^^ . . "3"^^ . . . "1"^^ . . . "Molekul\u00E1rn\u00ED charakteristika d\u011Btsk\u00FDch akutn\u00EDch myeloidn\u00EDch leukemi\u00ED a myelodysplastick\u00E9ho syndromu" . . . . "2012-06-30+02:00"^^ . "OC09051" . "Projekt zab\u00FDvaj\u00EDc\u00ED se molekul\u00E1rn\u00ED charakteristikou d\u011Btsk\u00FDch akutn\u00EDch myeloidn\u00EDch leukemi\u00ED a myelodysplastick\u00E9ho syndromu byl \u00FAsp\u011B\u0161n\u011B ukon\u010Den 4 publikacemi v presti\u017En\u00EDch mezin\u00E1rodn\u00EDch \u010Dasopisech (Leukemia, Haematologica, Cancer Letters) jedna v\u00FDznamn\u00E1 konsorci\u00E1ln\u00ED pr\u00E1ce vy\u0161la t\u00E9\u017E v \u010Dasopise Leukemia a dal\u0161\u00ED pr\u00E1ce jsou p\u0159ipraveny k publikaci."@cs . . . . "Usnadn\u011Bn\u00ED a zp\u0159esn\u011Bn\u00ED imunofenotypov\u00E9 diagnostiky a definice molekul\u00E1rn\u00ED remise d\u011Btsk\u00FDch AML a MDS definice role genu WT1 jako markeru MRN ov\u011B\u0159en\u00ED vyu\u017Eit\u00ED valproov\u00E9 kyseliny v l\u00E9\u010Db\u011B a identifikace genetick\u00FDch zm\u011Bn ve v\u00FDvoji (pre)leukemick\u00E9ho klonu." . . . . "childhood acute myeloid leukemia childhood myelodysplastic syndrome valproic acid HDACi AML1/ETO WT1 gene polychromatic flow cytometry arrayCGH minimal residual disease"@en . "2012-02-27+01:00"^^ . . "2009-04-01+02:00"^^ . "2013-06-28+02:00"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=OC09051"^^ . "Molecular characteristic of childhood acute myeloid leukemia and myelodysplastic syndrome"@en .