. . . . "2011-07-31+02:00"^^ . "19"^^ . "19"^^ . "Data will be obtained describing structural and biochemical properties of DNA modified by antitumor platinum and ruthenium complexes. These findings will be exploited for improvement of structure-pharmacological relationships of metallodrugs."@en . . "DNA; platinum; ruthenium; antitumor activity; antitumor drugs"@en . "2011-02-22+01:00"^^ . . . "Byly zji\u0161t\u011Bny \u00FAdaje o mechanismu protin\u00E1dorov\u00E9 \u00FA\u010Dinnosti nov\u00FDch nov\u00FDch komplex\u016F p\u0159echodn\u00FDch kov\u016F, zejm\u00E9na komplex\u016F platiny a ruthenia. Tyto komplexy pat\u0159\u00ED k nov\u00E9 generaci metalofarmak - slibn\u00FDch l\u00E9\u010Div proti rakovin\u011B, kter\u00E9 vykazuj\u00ED cytostatick\u00E9 efekty v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch rezistentn\u00EDch ke konven\u010Dn\u00ED cisplatin\u011B a jej\u00EDm analog\u016Fm vyu\u017E\u00EDvan\u00FDm v klinick\u00E9 praxi."@cs . " antitumor activity" . . "2012-07-12+02:00"^^ . "Molecular mechanisms underlying antitumor effects of new transition metal-based complexes, namely platinum and ruthenium complexes have been described. These complexes belong to the new generation of promising anticancer metallodrugs which exhibit antitumor effects in tumor cells resistant to conventional cisplatin and its analogues in clinical use."@en . . . . " platinum" . "Struktura, rozli\u0161en\u00ED a zpracov\u00E1n\u00ED po\u0161kozen\u00ED DNA protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDmi slou\u010Deninami kov\u016F" . . "Budou z\u00EDsk\u00E1ny poznatky o strukturn\u00EDch a biochemick\u00FDch vlastnostech DNA modifikovan\u00E9 protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDmi komplexy platiny a ruthenia. Tyto poznatky budou vyu\u017Eity ke zp\u0159esn\u011Bn\u00ED vztah\u016F mezi strukturou a farmakologickou aktivitou metalofarmak." . . " ruthenium" . . "OC08003" . . "0"^^ . . . . "1"^^ . "DNA" . "2008-01-01+01:00"^^ . . "Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance"@en . "http://www.isvav.cz/projectDetail.do?rowId=OC08003"^^ . "0"^^ . .