. "sysnt\u00E9za soubor\u016F struktur pro screening nov\u00FDch molekul s inhibi\u010Dn\u00ED aktivitou proti fyziologicky v\u00FDznamn\u00FDm glykosid\u00E1s\u00E1m."@cs . "Combinatorial chemistry in design of novel modulators of glycosidases function"@en . "Combinatorial chemistry; glycosidase"@en . . "synthesis of sets of structures for screening of new molecules wuth inhibition activity against physiologically significant glycosidases"@en . . . . . . . "Combinatorial chemistry" . . "0"^^ . . "The synthetic combinatorial libraries will be used for design of novel low-molecular weight inhibitors of glycosidases. The mimetics represent more effective and specific alternative to natural glycosidases inhibitors of saccharidic type. The mechanism o, f interaction of the novel inhibitors with the glycosidases will be characterized with the use of 3D molecular models. The project is focused on inhibitory regulation of the important target glycosidases involved in pathophysiological processes., ,"@en . "Kombinatorn\u00ED chemie a v\u00FDvoj nov\u00FDch modul\u00E1tor\u016F funkce glykosidas" . "3"^^ . "http://www.isvav.cz/projectDetail.do?rowId=OC D16.001"^^ . "0"^^ . "3"^^ . "C\u00EDlem projektu je v\u00FDvoj syntetick\u00FDch inhibitor\u016F glykosidas pomoc\u00ED technik kombinatorn\u00ED chemie. Tato mimetika p\u0159edstavuj\u00ED selektivn\u00ED a \u00FA\u010Dinn\u011Bj\u0161\u00ED alternativu k p\u0159irozen\u00FDm inhibitor\u016Fm glykosidas sacharidov\u00E9ho typu. Mechanismus interakce nov\u00FDch inhibitor\u016F s, glykosidasami bude charakterizov\u00E1n s vyu\u017Eit\u00EDm 3D molekul\u00E1rn\u00EDch model\u016F. Projekt se soust\u0159ed\u00ED na inhibi\u010Dn\u00ED regulaci v\u00FDznamn\u00FDch c\u00EDlov\u00FDch glykosidas \u00FA\u010Dastn\u00EDc\u00EDch se patofyziologick\u00FDch proces\u016F., ," . "OC D16.001" . "1"^^ . . . . . "2008-05-28+02:00"^^ . . . . . .