"Glycolipid A mimetics ? its chemo-enzymatic synthesis and immunological testing"@en . . . "glycomimetics" . . "septic shock" . "2004-06-16+02:00"^^ . "glycomimetics;lipid A;septic shock;aminosugars"@en . . "2"^^ . "0"^^ . "2"^^ . "1"^^ . "OC D13.50" . . . . "4 publikace v impaktovan\u00FDch \u010Dasopisech, p\u0159\u00EDprava nov\u00FDch l\u00E1tek, vypracov\u00E1n\u00ED p\u016Fvodn\u00ED metodiky testov\u00E1n\u00ED, biologick\u00E9 testov\u00E1n\u00ED"@cs . "New precursors of glycolipid A based on chitooligomers and aminosaccharides will be prepared using chemoenzymatic methods. New derivatives of glycolipid A will be tested for the imunogenicity and toxicity. Expected results - glycomimetics usable in septi, ic shock therapy., ,"@en . "lipid A" . . . . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=OC D13.50"^^ . . "Deriv\u00E1ty glykolipidu A, jeho chemoenzymatick\u00E1 synt\u00E9za a imunologick\u00E9 testov\u00E1n\u00ED" . . . . . . . . "Budou p\u0159ipraveny nov\u00E9 prekursory glykolipidu A pomoc\u00ED chemoenzymatick\u00FDch metod na b\u00E1zi chitooligomer\u016F a aminosacharid\u016F. Nov\u00E9 deriv\u00E1ty glykolipidu A p\u0159ipraven\u00E9 dal\u0161\u00EDmi \u010Dleny mezin\u00E1rodn\u00EDho konsorcia (WG) budou testov\u00E1ny na imunogenicitu a toxicitu. P\u0159edpok, l\u00E1dan\u00FDm v\u00FDsledkem by m\u011Blo b\u00FDt glykomimetikum, kter\u00E9 by byly pou\u017Eiteln\u00E9 v terapii septick\u00E9ho \u0161oku., ," .