"2014-03-21+01:00"^^ . "Nejv\u011Bt\u0161\u00EDm probl\u00E9mem tot\u00E1ln\u00ED endoprot\u00E9zy (TEP) ky\u010Dle je aseptick\u00E9 uvoln\u011Bn\u00ED a periprotetick\u00E1 osteol\u00FDza, kter\u00E9 jsou podm\u00EDn\u011Bny typem a rychlost\u00ED ot\u011Bru kloubn\u00EDch povrch\u016F. Opot\u0159eben\u00ED nen\u00ED prim\u00E1rn\u00ED funkc\u00ED artikula\u010Dn\u00EDch materi\u00E1l\u016F, n\u00FDbr\u017E d\u016Fsledkem interakc\u00ED \u0159ady faktor\u016F a podm\u00EDnek. Tyto faktory a podm\u00EDnky je mo\u017En\u00E9 d\u00EDlem simulovat in vitro a studovat pomoc\u00ED optick\u00E9 kolorimetrick\u00E9 interferometrie. Slo\u017Een\u00ED kloubn\u00ED kapaliny, tlakov\u00E9, rychlostn\u00ED a dal\u0161\u00ED parametry experimentu budou vych\u00E1zet z re\u00E1ln\u00E9 situace. Proto je sou\u010D\u00E1st\u00ED navrhovan\u00E9ho projektu tak\u00E9 anal\u00FDza re\u00E1ln\u00E9 kloubn\u00ED kapaliny z\u00EDskan\u00E9 v pr\u016Fb\u011Bhu reoperace/implantace TEP ky\u010Dle. V\u00FDstupy projektu budou vyu\u017Eiteln\u00E9 p\u0159i v\u00FDrob\u011B kloubn\u00EDch implant\u00E1t\u016F (materi\u00E1lov\u00E9 a konstruk\u010Dn\u00ED in\u017Een\u00FDrstv\u00ED), p\u0159i vysv\u011Btlen\u00ED rozd\u00EDl\u016F v rychlosti opot\u0159eben\u00ED, p\u0159e\u017Eit\u00ED implant\u00E1tu, resp. p\u0159i pochopen\u00ED biologick\u00FDch reakc\u00ED kolem TEP." . . "4"^^ . . . "4"^^ . "total hip arthroplasty" . "http://www.isvav.cz/projectDetail.do?rowId=NT14267"^^ . "1"^^ . " colorimetric i" . "1"^^ . . " aseptic loosening" . . "The main problem concerning total hip arthroplasty (THA) is aseptic loosening and periprosthetic osteolysis, both are related to the type and rate of joint surface wear. Wear is not a primary function of joint materials but is a result of the interaction of various factors and conditions. These factors and conditions can be simulated at least partially in vitro and analyzed using optic colorimetric interferometry. The composition of joint fluid, pressure, speed and other parameters of the experiment will evolve from the real situation. Therefore analysis of real joint effusions acquired during reoperation/ implantation of THA is part of the proposed study. Results of the project will be exploitable in the construction of joint implants (material and constructive engineering), in clarifying differences in wear rates, survival of implants, and also in understanding the biologic reactions around THA. Therefore, the proposed project is fully in accordance with the R&D program MH Czech Republic."@en . "0"^^ . . . "2015-01-22+01:00"^^ . "2015-12-31+01:00"^^ . "2013-05-01+02:00"^^ . " synovial fluid" . " film thickness" . . " rolling/sliding conditions" . . . "total hip arthroplasty; aseptic loosening; periprosthetic osteolysis; tribology; synovial fluid; lubrication; film thickness, colorimetric i; rolling/sliding conditions; friction"@en . . . " periprosthetic osteolysis" . " tribology" . . . . . "The influence of joint fluid composition on formation of lubricating film in THA"@en . "NT14267" . " lubrication" . "Vliv slo\u017Een\u00ED kloubn\u00ED kapaliny na utv\u00E1\u0159en\u00ED mazac\u00EDho filmu v TEP ky\u010Dle" . .