. " Mass Spectrometry" . "Ultra High Performance Liquid; Vitamin D; Mass Spectrometry, Extracorpor"@en . " Vitamin D" . . . "2013-05-01+02:00"^^ . "2015-12-31+01:00"^^ . . . . . . . "Projekt je zam\u011B\u0159en na v\u00FDvoj a validaci UHPLC metody s vyu\u017Eit\u00EDm nejnov\u011Bj\u0161\u00EDho syst\u00E9mu UFLC-Nexera pro stanoven\u00ED vitaminu D (D2 a D3) a jeho metabolit\u016F (25-OH D2, 25-OH D3) v lidsk\u00E9m s\u00E9ru s vyu\u017Eit\u00EDm modern\u00EDch technologi\u00ED jak v kapalinov\u00E9 chromatografii, tak v \u00FAprav\u011B biologick\u00E9ho materi\u00E1lu a p\u0159\u00EDprav\u011B vzorku k anal\u00FDze. V\u00FDvoj metody je iniciov\u00E1n po\u017Eadavky klinick\u00E9ho v\u00FDzkumu Fakultn\u00ED nemocnice Hradec Kr\u00E1lov\u00E9 (FNHK) . D\u016Fraz je kladen nejen na vlastn\u00ED v\u00FDzkum studie metabolismu vitaminu D, ale i na rychlost a jednoduchost dan\u00E9 metody, co\u017E by umo\u017Enilo jej\u00ED zaveden\u00ED do rutinn\u00EDho vy\u0161et\u0159en\u00ED nap\u0159. v biochemick\u00FDch laborato\u0159\u00EDch. V\u00FDsledkem t\u00E9to studie by proto m\u011Bl b\u00FDt p\u0159ehled o hladin\u00E1ch vitaminu D a jeho metabolit\u016F u vybran\u00E9 skupiny pacient\u016F. Po vyhodnocen\u00ED projektu by propojen\u00ED v\u00FDzkumn\u00FDch aktivit z oblasti analytick\u00E9 chemie a klinick\u00E9ho monitorov\u00E1n\u00ED m\u011Blo v\u00E9st ke zlep\u0161en\u00ED diagnostick\u00FDch mo\u017Enost\u00ED a z\u00E1rove\u0148 zkvalitn\u011Bn\u00ED l\u00E9\u010Debn\u00FDch postup\u016F u z\u00E1va\u017En\u00FDch civiliza\u010Dn\u00EDch chorob a zlep\u0161en\u00ED p\u00E9\u010De o jednotliv\u00E9 pacienty." . . "2015-01-22+01:00"^^ . "0"^^ . . "2014-03-21+01:00"^^ . "2"^^ . . "2"^^ . "1"^^ . . "NT14265" . "http://www.isvav.cz/projectDetail.do?rowId=NT14265"^^ . "Vyu\u017Eit\u00ED ultra vysoko\u00FA\u010Dinn\u00E9 kapalinov\u00E9 chromatografie s hmotnostn\u00ED detekc\u00ED pro stanoven\u00ED vitaminu D a jeho metabolit\u016F pro klinickou praxi" . . "The project focuses on the development and validation of UHPLC methods for determination of vitamin D and its metabolites (25-OH D2, 25-OH D3) in human serum using modern technology. Method development is initiated by clinical research requirements of the Teaching Hospital in Hradec Kralove. Emphasis is placed not only on own research studies of vitamin D metabolism, but also on the speed and simplicity of the method, which would allow its introduction into routine examinations such as biochemical laboratories. The result of this study should be therefore an overview of the levels of vitamin D and its metabolites in selected groups of patients. After evaluation of the project should link of research activities in the field of analytical chemistry and clinical monitoring lead to better diagnostic capabilities and also improve treatments for serious civilization diseases and improve the care of individual patients."@en . "Ultra High Performance Liquid" . "0"^^ . . . "Utilization of Ultra High Performance Liquid Chromatography with mass spectrometry detection for determination of vitamin D and it\u2019s metabolites for clinical practice"@en . .