. "1"^^ . "2014-03-21+01:00"^^ . "2015-01-22+01:00"^^ . "0"^^ . "\u010Casn\u00E1 diagnostika adenokarcinomu pankreatu: povrchov\u00E9 prote\u00E1zy a specifick\u00E9 biomarkery" . "The activites of surface proteases are increased dring pancreatic carcinogenesis. Their interactions with some biopeptides (incretins, pancreatic hormones, neuropeptides, and some others) enable the differential diagnosis of early PAC symptoms: differentiation of PAC diabetes from the common diabetes type 2 and the explanation of the decreasing body mass before the local symptoms appear. These procedures constitute the prerequisites for early PAC diagnosis in a significant proportion of affected subjects."@en . " new-onset diabetes" . "0"^^ . "2"^^ . . . "Early Diagnosis of Pancreatic Adenocarcinoma: Surface Proteases and Specific Biomarkers"@en . . "0"^^ . . . "Aktivita povrchov\u00FDch prote\u00E1z (DPP4, FAPalfa) je p\u0159i pankreatick\u00E9 karcinogenezi zv\u00FD\u0161ena. Jejich interakce s n\u011Bkter\u00FDmi biopeptidy (inkretiny, pankreatick\u00FDmi hormony, neuropeptidy aj.) umo\u017E\u0148uj\u00ED diferenci\u00E1ln\u00ED diagnostiku \u010Dasn\u00FDch symptom\u016F PAC (odli\u0161en\u00ED diabetu p\u0159i PAC od b\u011B\u017En\u00E9ho diabetu 2. typu a vysv\u011Btlen\u00ED poklesu t\u011Blesn\u00E9 hmotnosti) p\u0159ed objeven\u00EDm lok\u00E1ln\u00EDch p\u0159\u00EDznak\u016F . Tyto postupy vytv\u00E1\u0159ej\u00ED p\u0159edpoklady pro \u010Dasnou diagnostiku PAC a zlep\u0161en\u00ED progn\u00F3zy v\u00FDznamn\u00E9ho po\u010Dtu nemocn\u00FDch." . "2013-05-01+02:00"^^ . . . " pancreatic stroma" . " BMI decrease" . . "NT14254" . . . . . . . " surface proteases" . "http://www.isvav.cz/projectDetail.do?rowId=NT14254"^^ . " early diagnosis" . "2015-12-31+01:00"^^ . . . . "pancreatic adenocarcinoma" . . "pancreatic adenocarcinoma; new-onset diabetes; BMI decrease; early diagnosis; pancreatic stroma; surface proteases; biopeptides"@en .