. "1"^^ . "2014-03-21+01:00"^^ . "0"^^ . . "1"^^ . "0"^^ . . . . . "Gli\u00E1ln\u00ED n\u00E1dory p\u0159edstavuj\u00ED jednu z hlavn\u00EDch n\u00E1pln\u00ED neuroonkologick\u00E9ho programu. Epigenetick\u00E1 regulace genov\u00E9 exprese pomoc\u00ED DNA methylace a modifikace histon\u016F je zm\u011Bn\u011Bna v mnoha n\u00E1dorech v\u010Detn\u011B mozkov\u00FDch gliom\u016F. Epigenetick\u00E1 regulace prob\u00EDh\u00E1 na \u00FArovni hypermethylace DNA a posttransla\u010Dn\u00ED modifikace histon\u016F. V sou\u010Dasn\u00E9 dob\u011B bylo nalezeno mnoho aberantn\u011B methylovan\u00FDch gen\u016F v r\u016Fzn\u00FDch gli\u00E1ln\u00EDch tumorech. Bude sledov\u00E1no celkem 70 vybran\u00FDch gen\u016F s c\u00EDlem ur\u010Dit pod\u00EDl methylovan\u00FDch oblast\u00ED a jejich vliv na pr\u016Fb\u011Bh a progn\u00F3zu onemocn\u011Bn\u00ED. V\u00FDsledky projektu mohou identifikovat rizikov\u00E9 pacienty, individualizovat sledov\u00E1n\u00ED pacient\u016F a vybrat vhodn\u00FD typ l\u00E9\u010Dby na z\u00E1klad\u011B z\u00EDskan\u00FDch dat." . "0"^^ . "2013-05-01+02:00"^^ . . "Glial tumors are one of the main aim of the neuroonkological program. Epigenetic regulation of the gene expression caused by DNA methylation and histone post-translational modification is altered in many tumors including brain gliomas. Currently, many aberrantly methylated genes specific for different groups of gliomas were detected. In the proposed project, we will analyse 70 selected genes to determine the proportion of methylated regions and their influence on the course and disease prognosis. Project results can identify patients at risk, individualize monitoring of patients and to select appropriate type of treatment based on obtained data."@en . . "Epigenetick\u00E9 markery ovliv\u0148uj\u00EDc\u00ED chov\u00E1n\u00ED mozkov\u00FDch n\u00E1dor\u016F" . . . . " upgrading" . "hypermethylation; glioma; epigenetics; upgrading; methylator phenotype"@en . "http://www.isvav.cz/projectDetail.do?rowId=NT14253"^^ . . . "Epigenetic markers influencing the behavior of brain tumors"@en . . . . " glioma" . "2015-12-31+01:00"^^ . . "hypermethylation" . " epigenetics" . . . "NT14253" . "2015-01-22+01:00"^^ .