. . . "NT14145" . "Navrhovan\u00FD projekt v\u00FDznamn\u00FDm zp\u016Fsobem roz\u0161\u00ED\u0159\u00ED na\u0161e v\u011Bdomosti o p\u0159\u00EDtomnosti r\u016Fzn\u00FDch forem prionov\u00E9ho proteinu v krvi a likvoru pacient\u016F. Studie povede k implementaci nov\u00FDch diagnostick\u00FDch krit\u00E9ri\u00ED a biomarker\u016F u CJN, \u010D\u00EDm\u017E umo\u017En\u00ED zp\u0159esn\u011Bn\u00ED diagnostiky CJN i v \u010Dasn\u011Bj\u0161\u00EDch st\u00E1di\u00EDch. Samostatnou kapitolou je ot\u00E1zka ov\u011B\u0159en\u00ED specificity nov\u011B vyv\u00EDjen\u00FDch protil\u00E1tek proti glykovan\u00E9mu proteinu a jejich validace v r\u00E1mci diagnostiky CJN. V\u00FDznam a dopady projektu: Zp\u0159esn\u011Bn\u00ED \u010Dasn\u00E9 diagn\u00F3zy u pacient\u016F s CJN. Nalezen\u00ED dostupn\u00FDch a \u0161iroce pou\u017Eiteln\u00FDch klinick\u00FDch biomarker\u016F pro diagn\u00F3zu a prognostick\u00FDch faktor\u016F u CJN. Ov\u011B\u0159en\u00ED validity nov\u00FDch WHO diagnostick\u00FDch kriteri\u00ED v podm\u00EDnk\u00E1ch \u010Cesk\u00E9 Republiky. V\u00FDvoj nov\u00FDch klon\u016F protil\u00E1tek, kter\u00E9 se mohou uplatnit v diagnostice CJN." . . " prion" . "The proposed project aims to implement new diagnostic criteria and biomarkers in CJD into current practice leading to a more precise diagnosis of CJD at early stages. The project will enhance our knowledge about PrPc/PrPtse expression in blood and CSF of patients which is necessary for development of a specific diagnostic test. Obtained results will be published in impacted journal. An outstanding part is the verification of newly developed antibodies on relevant clinical material for improving diagnosis of human prion diseases. Anticipated results and impact: More precise early diagnosis of CJD. Identification of available and widely utilizable clinical biomarkers for diagnosis and prognostic factors in CJD. Verification of the validity of new WHO diagnostic criteria in Czech Republic settings. Development of a new clones of antibodies useable for diagnosis of human prion diseases."@en . . "2013-05-01+02:00"^^ . "Nov\u00E9 diagnostick\u00E9 p\u0159\u00EDstupy u Creutzfeldtovy-Jakobovy nemoci" . "1"^^ . " prion antibodies" . . "1"^^ . "2015-12-31+01:00"^^ . "4"^^ . "4"^^ . "2015-01-22+01:00"^^ . "2014-03-21+01:00"^^ . . . "0"^^ . . " biomarkers" . . . . . . "http://www.isvav.cz/projectDetail.do?rowId=NT14145"^^ . "New diagnostic approaches to Creutzfeldt-Jakob disease"@en . . "Creutzfeldt-Jakob disease" . "Creutzfeldt-Jakob disease; biomarkers; prion; prion antibodies; MRI"@en . . .