. "2013-05-01+02:00"^^ . "Projekt \u0159e\u0161\u00ED molekul\u00E1rn\u00ED biologii ovari\u00E1ln\u00EDch karcinom\u016F ve vztahu k odpov\u011Bdi na l\u00E9\u010Dbu. 1)Zhodnocen\u00ED genov\u00FDch polymorfism\u016F ABCB1,ABCC1,GST, protein\u016F Pgp, MRP1-k\u00F3dovan\u00FDch t\u011Bmito geny, chemorezistence/chemosensitivity in vitro (MTT test) u pacientek diagnostikovan\u00FDch 2013-2015 a retrospektivn\u011B u pacientek s ji\u017E stanoven\u00FDm Pgp, MRP1, MTT testem 2006-2009 ve vztahu k PFS a OS. 2) Stanoven\u00ED genov\u00FDch polymorfism\u016F interleukinu 8, genov\u00E9 exprese endoglinu,FGF,angiopoetinu a proangiogenn\u00EDch faktor\u016F(VEGF,TGF?,TGF\u00DF,bFGF) v z\u00E1vislosti na odpov\u011Bdi a typu prim\u00E1rn\u00ED l\u00E9\u010Dby u pacientek diagnostikovan\u00FDch 2013-2015 a retrospektivn\u011B z ovari\u00E1ln\u00ED n\u00E1dorov\u00E9 tk\u00E1n\u011B zamra\u017Een\u00E9 2006-2009. 3) Zhodnocen\u00ED kardiotoxicity paklitaxel+karboplatina versus paklitaxel+karboplatina+bevacizumab (EKG,TK,ECHOsrdce,markery kardiotoxicity NTproBNP,cTnT,cTnI,CKMB,MYO,hFABP,GPBB) a jej\u00ED vztah k chemorezistenci a genov\u00FDm polymorfism\u016Fm. Projekt umo\u017En\u00ED molekul\u00E1rn\u011B biologickou predikci odpov\u011Bdi na l\u00E9\u010Dbu u pacientek s karcinomem ovaria." . " MRP1" . . . " Pgp" . . . "This project is intent on assesment of molecular biology markers useful in prediction of therapeutic response in ovarian cancer patients by:1)Determination of ABCB1, ABCC1, GST polymorphisms, resistance proteins Pgp, MRP1, in vitro drug resistance/sensitivity and evaluation of their correlation with medical outcome (PFS, OS, side effects). 2) Assay of polymorphisms of the Interleukin-8 gene, endoglin, FGF, angiopoetin gene expression, pro-angiogenesis markers (VEGF,TGF?,TGF\u00DF,bFGF) and their correlation with kind of primary farmacotherapy and medical outcome (PFS, OS).3) Analysis of cardiotoxicity of standard primary chemotherapy (Paclitaxel + Carboplatin) versus primary therapy (Paclitaxel + Carboplatin + Bevacizumab) by ECG, blood pressure, ECHO, markers of cardiotoxicity (NT-proBNP,cTnT,cTnI,CKMB,MYO,h-FABP,GPBB) and their correlation with genetic polymophisms and drug resistance. This project support molecular biology prediction of the therapeutic response in ovarian cancer patients."@en . "Predikce odpov\u011Bdi na l\u00E9\u010Dbu u pacientek s karcinomem ovaria" . "ovarian cancer" . . "ovarian cancer; genetic polymorphism; Pgp; MRP1; VEGF; TGF; FGF; endoglin; angiopoetin; cardiotoxicity"@en . . "2015-12-31+01:00"^^ . " FGF" . "NT14107" . " VEGF" . "http://www.isvav.cz/projectDetail.do?rowId=NT14107"^^ . . . . "2014-03-21+01:00"^^ . " endoglin" . "Prediction of therapeutic response in ovarian cancer patients"@en . " TGF" . . . "1"^^ . "2"^^ . . "4"^^ . "4"^^ . " angiopoetin" . . " genetic polymorphism" . . "0"^^ . . . "2015-01-22+01:00"^^ .