"Endoscopically implantable duodeno-jejunal bypass (EBGL) as a new therapeutic option in obese 2-type diabetes patients: clinical efficacy and pathophysiological mechanisms of action"@en . "2014-07-17+02:00"^^ . "2013-05-01+02:00"^^ . . "Currently, the most effective bariatric surgical procedure is the gastric Roux-en-Y bypass; a similar effect (body weight reduction, Type-2 DM control) has been shown for endoscopically implantable duodeno-jejunal bypass based on the creation of a barrier between the duodenal and jejunal lumens on the one hand, and intestinal wall enterocytes using an endoscopically inserted plastic \u201Csleeve\u201C to exclude these segments of the small intestine from the process of digestion. While the exact mechanism of body weight reduction and, most importantly, type 2 DM control is still poorly understood, an effect of incretins is presumed. The aim of our project is to explore the effect of duodeno-jejunal bypass on incretin levels, insulin sensitivity, and other cardiovascular and metabolic parameters."@en . . "2015-01-22+01:00"^^ . "NT14083" . . . . " obesity" . "0"^^ . . . . . . . "1"^^ . "Nej\u00FA\u010Dinn\u011Bj\u0161\u00ED bariatrickou metodou sou\u010Dasnosti je operace Gastric Roux-en-Y bypass, podobn\u00FD efekt (pokles t\u011Blesn\u00E9 hmotnosti, kompenzace DM II. typu) m\u00E1 endoskopicky implantovateln\u00FD duodeno-jejun\u00E1ln\u00ED bypass, jeho\u017E principem je vytvo\u0159en\u00ED bari\u00E9ry mezi lumen duodena a jejuna a enterocyty st\u0159evn\u00ED st\u011Bny pomoc\u00ED endoskopicky zaveden\u00E9ho plastikov\u00E9ho \u201Eruk\u00E1vu\u201C, \u010D\u00EDm\u017E dojde k vy\u0159azen\u00ED t\u011Bchto \u010D\u00E1st\u00ED tenk\u00E9ho st\u0159eva z procesu digesce. P\u0159esn\u00FD mechanismus poklesu t\u011Blesn\u00E9 hmotnosti a hlavn\u011B kompenzace DM II. typu nen\u00ED zcela jasn\u00FD, p\u0159edpokl\u00E1d\u00E1 se vliv inkretin\u016F. C\u00EDlem na\u0161eho projektu je prozkoumat vliv duodeno-jejun\u00E1ln\u00EDho bypassu na hladiny inkretin\u016F, na inzul\u00EDnovou senzitivitu a dal\u0161\u00ED kardiovaskul\u00E1rn\u00ED a metabolick\u00E9 parametry." . . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NT14083"^^ . "2"^^ . "2015-12-31+01:00"^^ . "0"^^ . "Endoskopicky implantovateln\u00FD duodeno-jejun\u00E1ln\u00ED bypass (EBGL) jako nov\u00FD l\u00E9\u010Debn\u00FD p\u0159\u00EDstup u ob\u00E9zn\u00EDch diabetik\u016F 2. typu: klinick\u00E1 efektivita a patofyziologick\u00E9 mechanizmy \u00FA\u010Dinku" . "Duodenal-jejunal bypass sleeve" . . . . "Duodenal-jejunal bypass sleeve; obesity; type 2 diabetes mellitus"@en . . .