"Islet transplantation; Type 1 diabetes mellitus; Hypoglycemia unawareness syndr; Transplantation"@en . "2013-05-01+02:00"^^ . . . "0"^^ . "Transplantace izolovan\u00FDch Langerhansov\u00FDch ostr\u016Fvk\u016F dnes p\u0159edstavuje re\u00E1lnou mo\u017Enost l\u00E9\u010Dby vybran\u00FDch pacient\u016F s diabetem 1. typu se syndromem poru\u0161en\u00E9ho vn\u00EDm\u00E1n\u00ED hypoglyk\u00E9mie nebo t\u011Bch, kte\u0159\u00ED sou\u010Dasn\u011B podstupuj\u00ED transplantaci ledviny. Oproti org\u00E1nov\u00E9 transplantaci pankreatu se jedn\u00E1 o metodu mnohem bezpe\u010Dn\u011Bj\u0161\u00ED, ale dlouhodob\u00FD efekt t\u00E9to metody nen\u00ED dostate\u010Dn\u011B zn\u00E1m. C\u00EDlem projektu je posoudit, zda ve srovn\u00E1n\u00ED se stavem p\u0159ed transplantac\u00ED dojde ke spln\u011Bn\u00ED kompozitn\u00EDho ukazatele, kter\u00FD zahrnuje nep\u0159\u00EDtomnost z\u00E1va\u017En\u00FDch hypoglyk\u00E9mi\u00ED, hodnotu glykovan\u00E9ho hemoglobinu < 5,3 % a C-peptidu > 0,2 pmol/ml a redukci d\u00E1vek inzul\u00EDnu alespo\u0148 o 30% \u010Di jejich eliminaci a to za 6 a 12 m\u011Bs. po posledn\u00ED transplantaci. D\u00E1le budeme hotnotit zm\u011Bnu kvality \u017Eivota a variabilitu glyk\u00E9mi\u00ED m\u011B\u0159en\u00FDch kontinu\u00E1ln\u00EDm sensorem. V\u00FDvoj diabetick\u00E9 polyneuropatie a retinopatie bude sledov\u00E1n pomoc\u00ED EMG a retinofotografie. V\u00FDsledky se stanou objektivn\u00EDm podkladem pro indikaci ostr\u016Fvkov\u00E9 transplantace a jej\u00ED zd\u016Fvodn\u011Bn\u00ED." . "http://www.isvav.cz/projectDetail.do?rowId=NT14020"^^ . "Metabolic control and diabetes complications in clinical islet transplantation: a pilot study"@en . . "2015-01-22+01:00"^^ . . "2014-03-21+01:00"^^ . "Pr\u016Fb\u011Bh diabetu a jeho komplikac\u00ED po transplantaci Langerhansov\u00FDch ostr\u016Fvk\u016F" . "NT14020" . . . . " Type 1 diabetes mellitus" . . . "Pancreatic islet transplantation today represents a real treatment option for selected subjects with type 1 diabetes suffering from hypoglycemia unawareness syndrome or those who are listed for simultaneous kidney transplantation. Compared with organ pancreas transplantation, the procedure is much safer but long-term results have not been confirmed adequately yet. The aim or this project is to test, if it is possible using islet transplantation to achieve a composite end-point consisting of presence of all of the following criteria: HbA1c < 5.3 % (IFCC), C-peptide > 0.2 pmol/ml, insulin reduction by at least 30 % and complete absence of serious hypoglycemic episodes. The results will be assessed at 6 and 12 month and will be compared with the status before transplantation. In addition, quality of life, blood glucose variability measured by a continuous sensor, electromyography and retinophoto will be evaluated. The results will be used to support the rationales and funding of islet transplantation."@en . "0"^^ . . . . "Islet transplantation" . . " Hypoglycemia unawareness syndr" . . . "1"^^ . . "0"^^ . . "0"^^ . "2015-12-31+01:00"^^ .