. "http://www.isvav.cz/projectDetail.do?rowId=NT13847"^^ . "1"^^ . . "2015-12-31+01:00"^^ . "Diagnostick\u00FD a prognostick\u00FD v\u00FDznam vybran\u00FDch microRNA pro myelodysplastick\u00FD syndrom" . "2014-03-21+01:00"^^ . . . "1"^^ . "0"^^ . "1"^^ . "NT13847" . . . "Diagnostic and prognostic relevance of selected microRNAs in myelodysplastic syndromes"@en . . "myelodysplastic syndromes" . . . . . . " molecular markers" . " miRNA" . "2012-04-01+02:00"^^ . . . "Recently, analyses of gene expression identified several miRNAs (miR-34a, miR-224, miR-10a, miR-10b, miR-126, miR-181 family, miRNAs from commonly deleted region, miRNA cluster at 14q32, miR-29b) whose expression changes in patients with myelodysplastic syndromes (MDS) during the course of the disease or in response to its treatment. We suppose that these molecules may be implicated in disease development or progression. In the project, we want to prove applicability of these miRNAs as molecular markers for monitoring of MDS patients (by quantification of miRNA transcription by qRT-PCR) and to study them using an in vitro system."@en . "P\u0159ede\u0161l\u00E9 anal\u00FDzy genov\u00E9 exprese vedly k identifikaci n\u011Bkolika miRNA (miR-34a, miR-224, miR-10a, miR-10b, miR-126, rodina miR-181, miRNA z tzv. \u201Ccommonly deleted region\u201D, klastr miRNA na 14q32, miR-29b), jejich\u017E hladina se m\u011Bn\u00ED u pacient\u016F s myelodysplastick\u00FDm syndromem (MDS) v pr\u016Fb\u011Bhu onemocn\u011Bn\u00ED \u010Di jeho l\u00E9\u010Dby. Domn\u00EDv\u00E1me se, \u017Ee tyto molekuly mohou b\u00FDt asociov\u00E1ny s vznikem \u010Di progres\u00ED onemocn\u011Bn\u00ED. C\u00EDlem navrhovan\u00E9ho projektu bude ov\u011B\u0159en\u00ED vyu\u017Eitelnosti t\u011Bchto miRNA jako molekul\u00E1rn\u00EDch marker\u016F pro monitorov\u00E1n\u00ED pacient\u016F s MDS (metodou kvantifikace transkripce miRNA pomoc\u00ED qRT-PCR) a d\u00E1le jejich studium v in vitro syst\u00E9mu." . "2015-01-22+01:00"^^ . . "0"^^ . . "myelodysplastic syndromes; miRNA; molecular markers; expression"@en . .