"1"^^ . "2014-12-31+01:00"^^ . "1"^^ . " behaviour" . . "1"^^ . " alcohol dependence" . " sensitisation" . "1"^^ . . " alcoholic" . "0"^^ . . " morphine" . . . " fentanyl" . " antagonist" . " orexin" . " opioid dependence" . . . . . . " heroin" . . . " anxiety" . . . " craving" . " relaps" . "http://www.isvav.cz/projectDetail.do?rowId=NT13687"^^ . "2013-03-26+01:00"^^ . . "addiction" . "2012-04-01+02:00"^^ . "Aktu\u00E1ln\u011B vzr\u016Fst\u00E1 po\u010Det prac\u00ED je\u017E zkoumaj\u00ED vztahy mezi hormony ovliv\u0148uj\u00EDc\u00EDmi apetit (appetite regulating peptides; ARP), poruchami p\u0159\u00EDjmu potravy a drogov\u00FDmi z\u00E1vislostmi s nad\u011Bj\u00ED, \u017Ee studium povede k nalezen\u00ED nov\u00E9ho l\u00E9\u010Debn\u00E9ho p\u0159\u00EDstupu k z\u00E1vislostem. \u0158ada studi\u00ED tento p\u0159edpoklad podporuje zejm\u00E9na u alkoholismu, u opi\u00E1tov\u00E9 z\u00E1vislosti jsou tyto vztahy dosud minim\u00E1ln\u011B prob\u00E1dan\u00E9. Proto chceme v projektu studovat \u00FAlohu ghrelinu, orexinu, insulinu a leptinu u opi\u00E1tov\u00E9 z\u00E1vislosti (morfin, fentanyl), v experiment\u00E1ln\u00EDch modelech (i) abstinen\u010Dn\u00EDho syndromu, (ii) relapsu, (iii) strachu a \u00FAzkost\u00ED prov\u00E1zej\u00EDc\u00EDch z\u00E1vislost. V t\u011Bchto modelech (my\u0161i, potkani) ov\u011B\u0159\u00EDme p\u0159edpokl\u00E1dan\u00FD \u201El\u00E9\u010Debn\u00FD\u201C efekt antagonist\u016F ghrelinu a orexinu. K testov\u00E1n\u00ED vztah\u016F u\u017Eijeme metody (i) behaviour\u00E1ln\u00ED (explora\u010Dn\u00ED lokomoce; test aversivn\u00ED vokalizace; vyv\u00FD\u0161en\u00E9 bludi\u0161t\u011B), (ii) molekul\u00E1rn\u00ED (m\u011B\u0159en\u00ED plazmatick\u00FDch koncentrac\u00ED vybran\u00FDch ARP), (iii) neurochemick\u00E9 (CNS mikrodial\u00FDza in vivo). V klinick\u00E9 \u010D\u00E1sti dopln\u00EDme \u00FAdaje u heroinist\u016F a alkoholik\u016F." . " withdrawal" . "NT13687" . "addiction; appetite regulating peptides; opioid dependence; ghrelin; orexin; antagonist; morphine; fentanyl; withdrawal; relaps; sensitisation; craving; behaviour; anxiety; alcohol dependence; clinic; alcoholic; heroin; treatment"@en . "\u00DAloha peptidov\u00FDch hormon\u016F ovliv\u0148uj\u00EDc\u00EDch apetit v z\u00E1vislosti na opi\u00E1tech a alkoholu." . " ghrelin" . . " clinic" . . "Recently an increasing number of studies have been exploring the interrelations among appetite regulating peptides (ARP), food-intake disorders and drug dependencies with a hope for finding a new treatment approach to addiction. A number of studies support this supposal, particularly in alcoholism, however, in opioid dependence these interrelations has been only rarely studied yet. Thus, in the project we want to study the role of ghrelin, orexin, insulin, leptin in the opioid (morphine, fentanyl) dependence, using the experimental models of (i) abstinence syndrome, (ii) relaps, (iii) fear and anxiety. At these models (mice, rats) the presumed \u201Ctherapeutic\u201D effects of ghrelin and orexin antagonists will be tested. (i) Behavioural (explorative locomotion; aversive vocalization; elevated plus maze) (ii) molecular (measurement of ARP plasma concentrations) and (iii) neurochemical (CNS microdialysis in vivo) methods will be used. In the clinic the data in alcoholics and heroin addicts will be completed."@en . "2015-01-22+01:00"^^ . " appetite regulating peptides" . "The role of appetite regulating peptides in opioid and alcohol dependence."@en .