"bone biomarker; bone metastatic disease; scintigraphy; therapy of bone metastasis"@en . "bone biomarker" . "1"^^ . "0"^^ . "1"^^ . "1"^^ . "The subject of the study is a measurement of circulating levels of novel bone-turnover biomarkers and their comparison to the the traditional markers before scintigraphy. The obtained levels will be correlated to the results of the whole body skeletal scintigraphy. there will be enrolled 300 samples from patients with carcinoma of breast, lung and urogenital tract for whom the scintigraphy was indicated according to their diagnostics or during follow up. For marker measurements ther will be used up-to.date multiplex immunoanalytic technologies. The outcome of the project will be an algorithm for the measurements of bone turnover biomarkers measurements in oncology patients for the early detection, proper treatment tailoring, timing and follow up of bone metastatic disease."@en . . "Biomarkery kostn\u00ED metastatick\u00E9 nemoci" . . "2015-01-22+01:00"^^ . "2012-04-01+02:00"^^ . "Biomarkers of Bone Metastatic Disease"@en . . . . "P\u0159edm\u011Btem bude stanoven\u00ED hladin nov\u00FDch s\u00E9rov\u00FDch biomarker\u016F kostn\u00EDho obratu, v porovn\u00E1n\u00ED s klasick\u00FDmi, z n\u00E1b\u011Bru krve p\u0159ed proveden\u00EDm scintigrafie. Tyto hodnoty cirkuluj\u00EDc\u00EDch marker\u016F budou korelov\u00E1ny s v\u00FDsledky kostn\u00ED scintigrafie. Pl\u00E1nov\u00E1no je za\u0159azen\u00ED 300 pacient\u016F s malign\u00EDm onemocn\u011Bn\u00EDm plic,prsu a urogenit\u00E1ln\u00EDho traktu, u kter\u00FDch byla v r\u00E1mci jejich diagnozy indikov\u00E1na scintigrafie kost\u00ED i v r\u00E1mci follow up. V projektu budou vyu\u017Eity modern\u00ED multiplexov\u00E9 analytick\u00E9 technologie. V\u00FDsledkem projektu bude algoritmus pro vy\u0161et\u0159ov\u00E1n\u00ED biomarker\u016F kostn\u00EDho obratu u onkologick\u00FDch nemocn\u00FDch pro v\u010Dasn\u00E9 zachycen\u00ED, p\u0159esn\u00E9 na\u010Dasov\u00E1n\u00ED terapie a spr\u00E1vnou follow up u kostn\u00ED metastatick\u00E9 choroby." . . . . "2015-12-31+01:00"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=NT13655"^^ . "2014-03-21+01:00"^^ . "NT13655" . . . " bone metastatic disease" . . " scintigraphy" . "0"^^ . . . . .