"Applicability of a panel of molecular markers in clinical management of advanced gastric cancer"@en . . . "Projekt je zam\u011B\u0159en\u00FD na ov\u011B\u0159en\u00ED mo\u017Enosti praktick\u00E9ho pou\u017Eit\u00ED vybran\u00FDch molekul\u00E1rn\u00EDch marker\u016F (somatick\u00FDch mutac\u00ED a genov\u00FDch amplifikac\u00ED) v diagnostice, sledov\u00E1n\u00ED progrese a predikci dal\u0161\u00EDho chov\u00E1n\u00ED n\u00E1doru \u017Ealudku a mo\u017En\u00E9ho odhadu progn\u00F3zy pacient\u016F. Vy\u0161et\u0159ov\u00E1ny budou geny k\u00F3duj\u00EDc\u00ED kl\u00ED\u010Dov\u00E9 \u010Dleny sign\u00E1ln\u00EDch drah participuj\u00EDc\u00EDch na etiopatogenezi karcinomu \u017Ealudku. Jedn\u00E1 se p\u0159edev\u0161\u00EDm o geny k\u00F3duj\u00EDc\u00ED proteiny z oblasti receptorov\u00FDch i nonreceptorov\u00FDch proteinkin\u00E1z, sign\u00E1ln\u00EDch drah p\u016Fsob\u00EDc\u00EDch na proliferaci, diferenciaci, invazivitu a apopt\u00F3zu n\u00E1dorov\u00FDch bun\u011Bk (PI3K/Akt/PTEN, Ras/Raf/MAPK, Wnt/\u00DF-catenin a dal\u0161\u00ED dr\u00E1hy s nimi sdru\u017Een\u00E9) a kone\u010Dn\u011B faktory bun\u011B\u010Dn\u00E9 adheze, kontrololy bun\u011B\u010Dn\u00E9ho cyklu a tzv. DNA repair syst\u00E9m\u016F. Kandid\u00E1tn\u00ED markery budou identifikov\u00E1ny na z\u00E1klad\u011B detailn\u00ED liter\u00E1rn\u00ED re\u0161er\u0161e a jejich v\u00FDskyt v tumor\u00F3zn\u00ED tk\u00E1ni bude korelov\u00E1n s anamnestick\u00FDmi \u00FAdaji pacienta a klinick\u00FDmi parametry n\u00E1doru jako jsou st\u00E1dium, histologick\u00FD subtyp, apod." . " DNA" . " cancer" . "http://www.isvav.cz/projectDetail.do?rowId=NT13640"^^ . . . "NT13640" . "0"^^ . "2012-04-02+02:00"^^ . . . "1"^^ . . "stomach" . "1"^^ . "Uplatn\u011Bn\u00ED panelu molekul\u00E1rn\u00EDch marker\u016F v klinick\u00E9m managementu progreduj\u00EDc\u00EDho karcinomu \u017Ealudku" . . "The project is aimed to verify the practical use of selected molecular markers in the diagnosis, progression monitoring and prediction of further behavior of gastric cancer and the possible estimation of prognosis. The genes encoding key members of the signaling pathways participating in the etiopathogenesis of gastric cancer will be investigated. These are mainly genes coding proteins of the receptor and nonreceptor proteinkinases, signaling pathways involved in proliferation, differentiation, apoptosis and invasiveness of tumor cells (PI3K/Akt/PTEN, Ras / Raf / MAPK, Wnt / \u00DF-catenin and others with them associated) and finally, factors of cell adhesion, cell cycle control and the DNA repair systems. Candidate markers will be identified on the basis of a detailed literature search and their presence in tumor tissue be correlated with patient anamnestic data and clinical parameters such as tumor stage, histological subtype, etc."@en . . "6"^^ . "2015-01-22+01:00"^^ . "6"^^ . "2014-03-21+01:00"^^ . . " mutation" . . . . . . . "2015-12-31+01:00"^^ . . . . "stomach; cancer; DNA; mutation; gene amplification"@en .