"5"^^ . "5"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NT13569"^^ . "Identifikace prognostick\u00FDch a prediktivn\u00EDch faktor\u016F u pacient\u016F s nemalobun\u011B\u010Dn\u00FDm karcinomem plic podstupuj\u00EDc\u00EDch adjuvantn\u00ED chemoterapii." . . . . " tailored therapy" . "Non-small cell lung cancer; NSCLC; tumor; oncotherapy; immunohistochemical and geneti; tailored therapy; predictive medicine"@en . . "2015-12-31+01:00"^^ . "0"^^ . "2015-01-22+01:00"^^ . "1"^^ . . "1"^^ . . . " oncotherapy" . "Non-small cell lung cancer" . "\u2022 Study of selected molecular-genetic markers (EGFR, K-RAS and B-RAF mutation, ALK rearrangements, C-MET and EGFR amplification, expression of Pgp, MRP and LRP-1 proteins) in patients with NSCLC for elucidating of their predictive and prognostic significance. \u2022 Examination of 250 retrospective patients and approximately 120 prospectively enrolled patients with operable NSCLC treated with adjuvant chemotherapy based on cisplatin. \u2022 Modification of standard laboratory tests to increase individual mutation detection. \u2022 Preparation of a draft algorithm of biomarker examination for patients with NSCLC usable prior to adjuvant chemotherapy with the aim of individualizing therapy."@en . . "\u2022 Studium vybran\u00FDch molekul\u00E1rn\u011B-genetick\u00FDch marker\u016F (EGFR, K-RAS a B-RAF mutace, ALK p\u0159estavby, C-MET a EGFR amplifikace, exprese protein\u016F Pgp, MRP-1 a LRP) u pacient\u016F s NSCLC s c\u00EDlem objasn\u011Bn\u00ED jejich prediktivn\u00EDho a prognostick\u00E9ho v\u00FDznamu. \u2022 Vy\u0161et\u0159en\u00ED 250 pacient\u016F z retrospektivn\u00EDho souboru a p\u0159ibli\u017En\u011B 120 prospektivn\u011B za\u0159azen\u00FDch pacient\u016F s operabiln\u00EDm NSCLC, l\u00E9\u010Den\u00FDch adjuvantn\u00ED chemoterapi\u00ED zalo\u017Eenou na cisplatin\u011B. \u2022 Modifikace standardn\u00EDho laboratorn\u00EDho vy\u0161et\u0159en\u00ED pro zv\u00FD\u0161en\u00ED \u00FAsp\u011B\u0161nosti z\u00E1chytu jednotliv\u00FDch mutac\u00ED. \u2022 Na z\u00E1klad\u011B z\u00EDskan\u00FDch v\u00FDsledk\u016F p\u0159ipravit n\u00E1vrh algoritmu vy\u0161et\u0159en\u00ED jednotliv\u00FDch biomarker\u016F u pacient\u016F s NSCLC p\u0159ed zah\u00E1jen\u00EDm adjuvantn\u00ED chemoterapie se snahou o individualizaci l\u00E9\u010Dby." . " NSCLC" . . " immunohistochemical and geneti" . . " tumor" . "2014-03-21+01:00"^^ . . "NT13569" . . . . . . . "2012-04-01+02:00"^^ . "Identification of prognostic and predictive factors in non-small cell lung cancer patients treated by adjuvant chemotherapy."@en .