. . . . "intestinal ischemia; intestinal failure; bowel barrier function; peroperative damage"@en . "2012-04-01+02:00"^^ . "intestinal ischemia" . "0"^^ . . . . "Gastrointestin\u00E1ln\u00ED dysfunkce jako n\u00E1sledek peropera\u010Dn\u00ED isch\u00E9mie je zat\u00EDm p\u0159ehl\u00ED\u017Eenou p\u0159\u00ED\u010Dinou rozvoje \u0159ady poopera\u010Dn\u00EDch komplikac\u00ED. Jej\u00ED v\u010Dasn\u00E1 diagn\u00F3za a kvantifikace po\u0161kozen\u00ED tenk\u00E9ho st\u0159eva umo\u017En\u00ED zaveden\u00ED vhodn\u00FDch preventivn\u00EDch a l\u00E9\u010Debn\u00FDch opat\u0159en\u00ED. Vzhledem k neexistenci univerz\u00E1ln\u011B pou\u017Eiteln\u00E9ho markeru po\u0161kozen\u00ED st\u0159evn\u00ED sliznice je nutn\u00E9 vyvinout panel validovan\u00FDch vy\u0161et\u0159en\u00ED spolu s metodikou interpretace v\u00FDsledk\u016F. Tento panel bude vyvinut na souboru sta nemocn\u00FDch operovan\u00FDch pro karcinom kolorekta v otev\u0159en\u00E9 prospektivn\u00ED studii. Hodnoty biochemick\u00FDch marker\u016F po\u0161kozen\u00ED enterocyt\u016Fbudou n\u00E1sledn\u011B korelov\u00E1ny s klinick\u00FDmi projevy pozd\u011Bj\u0161\u00ED gastrointestin\u00E1ln\u00ED dysfunkce, rozvojem klinick\u00FDch komplikac\u00ED a d\u00E9lkou hospitalizace." . "1"^^ . . "2015-01-22+01:00"^^ . "0"^^ . "Gastrointestinal dysfunction as a consequence of perioperative ischemia is often overlooked cause of many complications after operative treatment. Its early diagnosis and quantification of small bowel damage enables possible preventive precautions or early treatment. Due to non-existence of universally valid marker of intestinal damage it is necessary to develop a chemistry panel of validated markers together with interpretation method. Such a panel will be developed on a cohort of 100 patients operated for colorectal carcinoma in open prospective study. The values of biochemical markers will be correlated with late clinical signs of gastrointestinal damage, complications and lenght of hospital stay."@en . . "V\u00FDvoj diagnostick\u00E9ho panelu pro monitorov\u00E1n\u00ED periopera\u010Dn\u00EDho po\u0161kozen\u00ED tenk\u00E9ho st\u0159eva" . "0"^^ . " intestinal failure" . . . "2014-03-21+01:00"^^ . . "2015-12-31+01:00"^^ . "0"^^ . . "NT13536" . " bowel barrier function" . . "http://www.isvav.cz/projectDetail.do?rowId=NT13536"^^ . "The development of diagnostic panel for monitoring of perioperative small bowel injury"@en . . . .