. . "http://www.isvav.cz/projectDetail.do?rowId=NT13523"^^ . "chronic neuropathic pain; multiple sclerosis; chronic low back pain; quantitative sensory testing; conditioned pain modulation; diffuse noxious inhibitory con; temporal summation"@en . . "The project is focused on the extension of the knowledge about pathophysiology of various types of neuropathic pain, in particular central neuropathic pain in multiple sclerosis and combined pain of nociceptive and peripheral neuropathic origin in chronic low back pain patients using the methods of quantitative sensory testing and their dynamic applications. The project will be carried out by cross-sectional study of the perception of pain and other sensory modalities and evaluation of the function of central modulatory mechanisms engaged in pain perception in large and well-defined groups of patients with chronic pain of the above mentioned etiology, healthy volunteers and patients with multiple sclerosis without any pain. The obtained results will be evaluated in relation to clinical examination, EMG and evoked potencuals and probable importance of the tested mechanisms in the pathophysiology of chronic pain in patients with multiple sclerosis and chronic low back pain will be assessed."@en . . " quantitative sensory testing" . " chronic low back pain" . . "2012-04-01+02:00"^^ . . . . . . "2015-12-31+01:00"^^ . " multiple sclerosis" . " conditioned pain modulation" . "Specifick\u00E9 charakteristiky neuropatick\u00E9 bolesti centr\u00E1ln\u00EDho a perifern\u00EDho typu" . . "chronic neuropathic pain" . "NT13523" . . . "2014-03-21+01:00"^^ . " diffuse noxious inhibitory con" . . "Specific characteristics of neuropathic pain of central and peripheral type"@en . "0"^^ . . . "2015-01-22+01:00"^^ . "1"^^ . "0"^^ . "1"^^ . "0"^^ . "Projekt je zam\u011B\u0159en na roz\u0161\u00ED\u0159en\u00ED poznatk\u016F o patofyziologii chronick\u00E9 bolesti a to zejm\u00E9na centr\u00E1ln\u00ED neuropatick\u00E9 bolesti p\u0159i roztrou\u0161en\u00E9 skler\u00F3ze a bolesti sm\u00ED\u0161en\u00ED perifern\u00ED neuropatick\u00E9 a nociceptivn\u00ED u pacient\u016F s chronick\u00FDm lumbagem s vyu\u017Eit\u00EDm metod kvantitativn\u00EDho testov\u00E1n\u00ED senzitivity a jejich dynamick\u00FDch aplikac\u00ED. Projekt bude realizov\u00E1n pomoc\u00ED pr\u016F\u0159ezov\u00E9ho detailn\u00EDho zhodnocen\u00ED percepce \u0159ady senzitivn\u00EDch modalit v\u010Detn\u011B bolesti a posouzen\u00ED funkce jej\u00EDch centr\u00E1ln\u00EDch modula\u010Dn\u00EDch mechanism\u016F u rozs\u00E1hl\u00E9ho souboru pacient\u016F s chronickou bolest\u00ED v\u00FD\u0161e zm\u00EDn\u011Bn\u00E9 etiologie, zdrav\u00FDch kontrol a pacient\u016F s roztrou\u0161enou skler\u00F3zou bez neuropatick\u00E9 bolesti. Z\u00EDskan\u00E9 n\u00E1lezy budou vyhodnoceny ve vztahu ke klinicky \u010Di elektrofyziologicky prok\u00E1zan\u00FDm zn\u00E1mk\u00E1m dysfunkce centr\u00E1ln\u00EDho \u010Di perifern\u00EDho nervov\u00E9ho syst\u00E9mu a n\u00E1lez\u016Fm zobrazovac\u00EDch metod a bude zhodnocen jejich v\u00FDznam v patofyziologii chronick\u00E9 bolesti u roztrou\u0161en\u00E9 skler\u00F3zy a chronick\u00E9ho lumbaga." . .