"Hypokinetick\u00E1 dysartrie (HD) pat\u0159\u00ED mezi nej\u010Dast\u011Bj\u0161\u00ED a ji\u017E \u010Dasn\u00E9 p\u0159\u00EDznaky PN, kter\u00E9 jsou obt\u00ED\u017En\u011B ovlivniteln\u00E9 b\u011B\u017Enou medikac\u00ED a/nebo chirurgi\u00ED PN. P\u0159itom sn\u00ED\u017Een\u00E1 schopnost komunikace prokazateln\u011B sni\u017Euje kvalitu \u017Eivota lid\u00ED s PN. A\u010Dkoliv n\u011Bkter\u00E9 dal\u0161\u00ED axi\u00E1ln\u00ED symptomy PN (nap\u0159. postur\u00E1ln\u00ED instabilita a poruchy ch\u016Fze) predikuj\u00ED rozvoj demence u PN, nen\u00ED jasn\u00E9, jak\u00FD je vztah mezi HD a kognitivn\u00ED deteriorac\u00ED. Projekt m\u00E1 za c\u00EDl jednak zjistit, jak\u00E9 specifick\u00E9 motorick\u00E9 poruchy \u0159e\u010Di jsou charakteristick\u00E9 pro PN v z\u00E1vislosti na r\u016Fzn\u00FDch demografick\u00FDch a klinick\u00FDch parametrech (ve srovn\u00E1n\u00ED s v\u011Bkov\u011B v\u00E1zan\u00FDmi kontrolami) a jednak zjistit, jak\u00FD je vztah mezi klinick\u00FDmi a fyzik\u00E1ln\u00EDmi parametry HD a kognitivn\u00ED deteriorac\u00ED. D\u00EDl\u010D\u00ED c\u00EDle jsou zam\u011B\u0159eny na v\u00FDzkum efektu terapie PN a jeho patofyziologick\u00FDch mechanism\u016F a na efekt rTMS na specifick\u00E9 parametry HD. V\u00FDsledky v\u00FDzkumu umo\u017En\u00ED zefektivnit logopedickou p\u00E9\u010Di pacient\u016F s PN a mohou pomoci v hled\u00E1n\u00ED vhodn\u00FDch marker\u016F pro rozvoj kognitivn\u00ED poruchy a demence u PN." . "NT13499" . "2015-12-31+01:00"^^ . " repetitive transcranial magnet" . . . . . . . "\u0158e\u010D, jej\u00ED poruchy a kognitivn\u00ED funkce u Parkinsonovy nemoci" . . . " dementia" . . "6"^^ . " physical parameters of speech" . "Parkinson's disease; speech; hypokinetic dysarthria; cognitive impairment; dementia; physical parameters of speech; repetitive transcranial magnet; functional magnetic resonance"@en . "6"^^ . "2015-01-22+01:00"^^ . " cognitive impairment" . . "http://www.isvav.cz/projectDetail.do?rowId=NT13499"^^ . . . . "Hypokinetic dysarthria (HD) belongs to the most common early symptoms of PD, which are difficult to treat by antiparkinsonian medication and/or surgical treatment. Impaired ability of communication significantly reduces the quality of life of PD subjects. Although some other axial symptoms of PD (e.g. postural instability/gait difficulty) are predictors of the development of dementia in PD, the relationship between HD and cognitive impairment is not clear. The aims of the project are firstly to identify the specific disorders of speech which are characteristic of PD depending on various demographic and clinical variables and secondly to identify the relationship between specific parameters of HD and cognitive impairment. Partial aims are to explore effects of PD treatment, its pathophysiological mechanisms, and the effect of rTMS on HD. The results will make the speech therapy in PD patients more efficient and may help to find suitable biomarkers for cognitive impairment and dementia in PD."@en . " speech" . "0"^^ . " hypokinetic dysarthria" . "Parkinson's disease" . . "1"^^ . "1"^^ . . "2014-03-21+01:00"^^ . "Speech, its impairment and cognitive performance in Parkinson's disease"@en . "2012-04-01+02:00"^^ . . .