" colorectal adenoma and carcino" . . "0"^^ . . . "Apoptosis; colorectal epithelium; inflammatory bowel disease; colorectal adenoma and carcino; colonoscopy; biopsies; mucosal pH; bacteriocins."@en . . . . . . "Stanoven\u00ED apopt\u00F3zy v biopticky odebran\u00FDch vzorc\u00EDch z tlust\u00E9ho st\u0159eva" . "2015-12-31+01:00"^^ . "Apoptosis" . . . "Apopt\u00F3za bun\u011Bk sliznice tlust\u00E9ho st\u0159eva je u zdrav\u00E9ho \u010Dlov\u011Bka velmi n\u00EDzk\u00E9ho stupn\u011B. Faktory, kter\u00E9 apopt\u00F3zu kolorekta ovliv\u0148uj\u00ED (zvy\u0161uj\u00ED), nejsou dosud uspokojiv\u011B objasn\u011Bny. Vedle z\u00E1kladn\u00EDho onemocn\u011Bn\u00ED (idiopatick\u00FD st\u0159evn\u00ED z\u00E1n\u011Bt, adenom, karcinom) to mohou b\u00FDt lumin\u00E1ln\u00ED a slizni\u010Dn\u00ED pH, odli\u0161n\u00E1 exprese krevn\u011B skupinov\u00FDch antigen\u016F, zm\u011Bny slizni\u010Dn\u00EDch prostaglandin\u016F a protein\u016F rodiny S100, mikrobiota, nutri\u010Dn\u00ED vlivy aj. Projekt vyu\u017Eije pokro\u010Dil\u00E9 zobrazovac\u00ED metody, nejmodern\u011Bj\u0161\u00ED mo\u017Enosti stanoven\u00ED apopt\u00F3zy bioptick\u00FDch vzork\u016F odebran\u00FDch p\u0159i koloskopii, proteomick\u00E9 mapy, direktn\u00ED m\u011B\u0159en\u00ED pH a bakteriocinogenotypizaci." . " mucosal pH" . . . "Determination of apoptosis in the bioptic samples taken from the colon"@en . " colorectal epithelium" . " biopsies" . " inflammatory bowel disease" . "2014-03-21+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NT13413"^^ . "4"^^ . " colonoscopy" . "NT13413" . "2012-04-01+02:00"^^ . "4"^^ . "1"^^ . . . "2015-01-22+01:00"^^ . . "2"^^ . . "Apoptosis of colonic epithelial cells is of a very low degree in healthy humans. Factors, which influence (increase) apoptosis, have not been satisfactory explained yet. Not only primary disease itself (inflammatory bowel disease, adenoma, carcinoma), but also luminal pH and pH of the mucosa, different expression of blood group antigens, alteration of mucosal prostaglandines and S100 proteins, microbial population, nutrition etc. may play a role in apoptosis. The project will use advanced endoscopic methods, most modern possibilities of apoptosis determination in the bioptic samples (taken during colonoscopy), direct measurement of mucosal pH and bacteriocinogenotypization."@en .