. "0"^^ . " prognosis" . "Complex assessment of microenvironment and its impact on clinical course of chronic lymphocytic leukemia."@en . . "0"^^ . "2014-03-21+01:00"^^ . "1. Zhodnocen\u00ED vybran\u00FDch ukazatel\u016F mikroprost\u0159ed\u00ED u CLL - membr\u00E1nov\u00E9 antigeny (CD54, CD49d, CD31, CD105), plazmatick\u00E9 cytokiny (sCD105, angiopoetin-2, endostatin, trombospondin-1, TGF-beta1), geny ovliv\u0148uj\u00EDc\u00ED angiogenezi (FGF-2, CD105) a cirkuluj\u00EDc\u00ED endoteli\u00E1ln\u00ED bu\u0148ky pomoc\u00ED pr\u016Ftokov\u00E9 cytometrie, real-time kvantitativn\u00ED PCR a ELISA, a to v dob\u011B diagn\u00F3zy, p\u0159i progresi, po l\u00E9\u010Db\u011B a p\u0159i relapsu CLL. 2. Posouzen\u00ED vztahu marker\u016F mikroprost\u0159ed\u00ED k z\u00E1sadn\u00EDm klinick\u00FDm a laboratorn\u00EDm parametr\u016Fm (klinick\u00E9 st\u00E1dium, zdvojovac\u00ED \u010Das lymfocyt\u016F, exprese protein\u016F CD38 a ZAP-70, muta\u010Dn\u00ED stav IgVH, cytogenetick\u00E9 aberace) a klinick\u00E9mu pr\u016Fb\u011Bhu CLL (doba do zah\u00E1jen\u00ED l\u00E9\u010Dby, l\u00E9\u010Debn\u00E1 odpov\u011B\u010F, obdob\u00ED bez progrese, celkov\u00E9 p\u0159e\u017Eit\u00ED)." . " angiogenesis" . "1"^^ . " microenvironment" . "1. Assessment of selected markers of microenvironment in CLL: membrane antigens (CD49d, CD31, CD105, CD54), circulating plasma proteins (sCD105, angiopoietin-2, endostatin, thrombospondin-1, TGF-beta1), genes affecting angiogenesis (FGF-2, CD105), and circulating endothelial cells, by means of flow cytometry, real-time quantitative PCR a ELISA performed at at the time of diagnosis, progression, after treatment, and at relapse. 2. Exploration of the relationship between the vztahu markers of microenvironment and crucial clinical and laboratory parameters (clinical stage, lymphocyte doubling time, expresssion of CD38 a ZAP-70, IgVH mutation status, cytogenetic aberrations detected by FISH) and clinical course of CLL (time to treatment, therapeutic response, progression-free- and overall survival)."@en . . "http://www.isvav.cz/projectDetail.do?rowId=NT13412"^^ . . . . "NT13412" . "8"^^ . "Komplexn\u00ED hodnocen\u00ED vlivu mikroprost\u0159ed\u00ED na klinick\u00FD pr\u016Fb\u011Bh chronick\u00E9 lymfocyt\u00E1rn\u00ED leuk\u00E9mie" . "8"^^ . . "chronic lymphocytic leukemia" . . . . . . . "2015-01-22+01:00"^^ . " chemoresistance" . "chronic lymphocytic leukemia; microenvironment; angiogenesis; prognosis; chemoresistance; circulating endothelial cells."@en . . "2015-12-31+01:00"^^ . "2012-04-01+02:00"^^ . . . .