. . . "Early markers of bipolar disorder: from genetic risk to first symptoms"@en . "Rann\u00E9 markery bipol\u00E1rn\u00ED afektivn\u00ED poruchy: od genetick\u00E9ho rizika k prvn\u00EDm symptom\u016Fm" . "2012-04-01+02:00"^^ . "NT13337" . " adolescents" . . . . " early markers" . "Prospective observation of subjects at risk of developing bipolar disorder (the offspring of bipolar parents) The objective is to catch first psychopathology and stalk its development with purpose to identify clinical, neuropsychological and electrophysiological markers. Results will be compared with age, gender and level of education matched offspring of parents without psychiatric illness Total sample will consist of 70 high-risk offspring and 70 controls aged 7-18 years. Semistructured interview, will be repeated annually, while screening psychiatric symptoms and QoL questionaires will be administered every 3 month. Sleep will be monitored for 7 days every 3 month using actigraph. Cognitive functions and emotional components in event related potential will be axamined in the entrance and after two years. We will assess the between-group difference in the symptom presence and course, the occurence of new mental illness, in cognitive functions test outcome and ERP components of emotion processing."@en . . . . " children" . . . "bipolar affective disorder" . " endophenotypes" . . "2014-03-21+01:00"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=NT13337"^^ . . . "2015-01-22+01:00"^^ . "0"^^ . "bipolar affective disorder; children; adolescents; high-risk offsprings; early markers; endophenotypes; prospective study"@en . "1"^^ . . "1"^^ . "Studie je zalo\u017Eena na prospektivn\u00EDm sledov\u00E1n\u00ED d\u011Bt\u00ED a adolescent\u016F v riziku rozvoje bipol\u00E1rn\u00ED afektivn\u00ED poruchy (potomk\u016F rodi\u010D\u016F s bipol\u00E1rn\u00ED afektivn\u00ED poruchou). C\u00EDlem je zachytit v\u00FDskyt a v\u00FDvoj psychopatologie od prvn\u00EDch symptom\u016F a identifikovat rann\u00E9 markery bipol\u00E1rn\u00ED afektivn\u00ED poruchy. Kontrolami budou v\u011Bkem, pohlav\u00EDm a stupn\u011Bm vzd\u011Bl\u00E1n\u00ED p\u00E1rovan\u00ED potomci zdrav\u00FDch rodi\u010D\u016F. Do projektu bude za\u0159azeno 70 rizikov\u00FDch potomk\u016F a 70 kontroln\u00EDch subjekt\u016F ve v\u011Bku 7 a\u017E 18 let. Psychiatrick\u00E1 symptomatika bude hodnocena semistrukturovan\u00FDm interview, kter\u00E9 bude opakov\u00E1no s odstupem 1roku a pr\u016Fb\u011B\u017En\u011B sledov\u00E1na screeningov\u00FDmi dotazn\u00EDky po 3 m\u011Bs\u00EDs\u00EDch, stejn\u011B jako kvalita \u017Eivota. Sp\u00E1nek bude vy\u0161et\u0159ov\u00E1n aktigraficky po dobu 7 dn\u00ED v\u017Edy po 3 m\u011Bs\u00EDc\u00EDch. Neuropsychologick\u00E9 vy\u0161et\u0159en\u00ED a vy\u0161et\u0159en\u00ED emo\u010Dn\u00EDch komponent ERP prob\u011Bhne p\u0159i vstupu do studie a po 2 letech. Sledov\u00E1n bude meziskupinov\u00FD rozd\u00EDl ve v\u00FDskytu a v\u00FDvoji psychopatologie a kandid\u00E1tn\u00EDch marker\u016F preklinick\u00FDch st\u00E1di\u00ED bipol\u00E1rn\u00ED afektivn\u00ED poruchy." . " high-risk offsprings" . "2015-12-31+01:00"^^ . "1"^^ . "1"^^ .