. "Multiple sclerosis (MS) is a chronic disorder of the nervous system that affects mainly young individuals. In the majority of patients, the untreated disease leads to serious impairment. We currently have no cure for MS, however, with the help of timely anti-inflammatory therapy we are able to ameliorate its course. Efficacy of the available treatments in individual patients is highly variable. Therefore the exact quantification of disease activity are crucial. For this purpose, the currently available clinical variables (relapses and EDSS) are of a limited value. The aim of this project is to identify markers with improved individual descriptive and predictive values. Among the candidate parameters we will test relapse severity, MSFC and neuropsychological tests. Furthermore, we will evaluate novel MRI protocols, i.e. global and regional brain atrophy, as these are expected to show higher sensitivity than the conventional MRI protocols. Finally, optic coherence tomography will be included."@en . . . "13"^^ . "Klinick\u00E9 a paraklinick\u00E9 markery roztrou\u0161en\u00E9 skler\u00F3zy \u2013 korelace se sou\u010Dasn\u00FDm stavem pacienta a predikce pr\u016Fb\u011Bhu nemoci." . "13"^^ . . . "0"^^ . "NT13237" . "2015-01-22+01:00"^^ . " surrogate markers" . "Roztrou\u0161en\u00E1 skler\u00F3za (RS) je chronick\u00E9 onemocn\u011Bn\u00ED nervov\u00E9ho syst\u00E9mu postihuj\u00EDc\u00ED p\u0159ev\u00E1\u017En\u011B mlad\u00E9 jedince. U v\u011Bt\u0161iny nemocn\u00FDch zp\u016Fsobuje nemoc bez l\u00E9\u010Dby z\u00E1va\u017Enou invaliditu b\u011Bhem 10-20 let. RS neum\u00EDme vyl\u00E9\u010Dit, jsme pouze schopni zpomalit jej\u00ED pr\u016Fb\u011Bh pomoc\u00ED v\u010Dasn\u00E9 protiz\u00E1n\u011Btliv\u00E9 l\u00E9\u010Dby. \u00DA\u010Dinnost dostupn\u00FDch l\u00E9k\u016F je ov\u0161em u individu\u00E1ln\u00EDch pacient\u016F vysoce variabiln\u00ED. Proto jsou p\u0159esn\u00E1 kvantifikace aktivity nemoci a spr\u00E1vn\u00E1 identifikace odpov\u00EDdavosti na jednotliv\u00E9 l\u00E9ky kl\u00ED\u010Dov\u00E9. V sou\u010Dasnosti u\u017E\u00EDv\u00E1n\u00E9 klinick\u00E9 prom\u011Bnn\u00E9 (ataky a \u0161k\u00E1la EDSS) jsou pro tyto \u00FA\u010Dely nedosta\u010Duj\u00EDc\u00ED. C\u00EDlem projektu je identifikovat klinick\u00E9 a paraklinick\u00E9 parametry s lep\u0161\u00ED individu\u00E1ln\u00ED popisnou a prediktivn\u00ED hodnotou. Mezi testovan\u00E9 klinick\u00E9 parametry zahrneme z\u00E1va\u017Enost atak, hodnot\u00EDc\u00ED \u0161k\u00E1lu MSFC a neuropsychologick\u00E9 testy. D\u00E1le budeme testovat nov\u00E9 metody magnetick\u00E9 rezonance, jako je celkov\u00E1 a region\u00E1ln\u00ED atrofie mozku, kter\u00E9 jsou specifi\u010Dt\u011Bj\u0161\u00ED ne\u017E konven\u010Dn\u00ED rezonan\u010Dn\u00ED postupy. Novou testovanou metodou bude optick\u00E1 koherentn\u00ED tomografie." . "0"^^ . . . . "multiple sclerosis; surrogate markers; magnetic resonance imaging; optical coherence tomography; neuropsychology; individual prediction"@en . "http://www.isvav.cz/projectDetail.do?rowId=NT13237"^^ . . "1"^^ . . . . . "2014-03-21+01:00"^^ . . " magnetic resonance imaging" . . "2015-12-31+01:00"^^ . . "Clinical and paraclinical markers of multiple sclerosis \u2013 description and prediction of disease activity"@en . . " neuropsychology" . "multiple sclerosis" . "2012-04-01+02:00"^^ . " optical coherence tomography" .