"n-3PUFA; fish oil; olive oil; home parenteral nutrition; lipid emulsion; endotoxin stimulation; inflammation; oxidative stress; sepsis"@en . . . . . . "2012-04-01+02:00"^^ . . . "2015-12-31+01:00"^^ . "Effects of different fatty acid composition in home parenteral nutrition formula on lipid metabolism and inflammatory markers"@en . "The project should contribute to optimisation of FA representation in the lipid emulsions administered by parenteral nutrition. The patients on long-term home parenteral nutrition, will be gradually given three ten-week cycles of complete parenteral nutriton using three different parenteral nutrition fat emulsions (Clinoleic \u00AE, Lipoplus \u00AE, Smof lipid \u00AE). After 6 weeks in each cycle an increased dose of fish oil in the form of Omegaven\u00AE will follow for remaining 4 weeks. In the course of individual cycles, the clinical state, nutrition balance, liver tests, hemocoagulation and other indicators of tolerance will be monitored. The spectrum of FA in blood lipids, other lipid parameters, inflammatory markers including in vitro whole blood leukocyte stimulation with endotoxin, redox balance markers will be determined after each cycle. The results of the study will help in finding the optimal composition of the fat emulsion, not only for long-term parenteral nutrition, but also during acute inflammation."@en . " lipid emulsion" . " olive oil" . " inflammation" . "2014-03-21+01:00"^^ . " oxidative stress" . . "Projekt by m\u011Bl p\u0159isp\u011Bt k optimalizaci zastoupen\u00ED jednotliv\u00FDch t\u0159\u00EDd FA v tukov\u00FDch emulz\u00EDch parenter\u00E1ln\u00ED v\u00FD\u017Eivy aplikovan\u00E9 pacient\u016Fm se st\u0159evn\u00ED nedostate\u010Dnost\u00ED. Ka\u017Ed\u00E9mu z pacient\u016F budou v 10 t\u00FDdenn\u00EDch cyklech postupn\u011B pod\u00E1v\u00E1ny v kompletn\u00ED parenter\u00E1ln\u00ED v\u00FD\u017Eiv\u011B t\u0159i r\u016Fzn\u00E9 tukov\u00E9 emulze (Clinoleic\u00AE, Lipoplus\u00AE, Smof lipid\u00AE), po 6. t\u00FDdnu v\u017Edy dopln\u011Bn\u00E9 na dal\u0161\u00ED 4 t\u00FDdny o zv\u00FD\u0161enou d\u00E1vku ryb\u00EDho tuku ve form\u011B emulze Omegaven\u00AE. V pr\u016Fb\u011Bhu studie bude pravideln\u011B monitorov\u00E1n klinick\u00FD stav, nutri\u010Dn\u00ED bilance, jatern\u00ED testy, hemokoagulace a dal\u0161\u00ED ukazatel\u00E9 tolerance. Po skon\u010Den\u00ED ka\u017Ed\u00E9ho cyklu parenter\u00E1ln\u00ED v\u00FD\u017Eivy bude stanovov\u00E1no spektrum FA v lipidech plazmy a erytrocyt\u016F, ostatn\u00ED lipidov\u00E9 parametry, hladiny antioxidant\u016F, ukazatel\u00E9 oxida\u010Dn\u00EDho stresu a z\u00E1n\u011Btu, v\u010Detn\u011B reaktivity leukocyt\u016F in vitro p\u0159ed a po stimulaci endotoxinem. V\u00FDsledky t\u00E9to studie pomohou p\u0159i volb\u011B optim\u00E1ln\u00EDho slo\u017Een\u00ED tukov\u00E9 emulze nejen pro dlouhodobou parenter\u00E1ln\u00ED v\u00FD\u017Eivu, ale zejm\u00E9na p\u0159i stavech akutn\u00EDho z\u00E1n\u011Btu (periopera\u010Dn\u00ED stavy, kriticky nemocn\u00ED)." . . . "1"^^ . "0"^^ . "1"^^ . "0"^^ . "n-3PUFA" . " fish oil" . . "NT13236" . . "0"^^ . "2015-01-22+01:00"^^ . " home parenteral nutrition" . " endotoxin stimulation" . "http://www.isvav.cz/projectDetail.do?rowId=NT13236"^^ . "Vliv r\u016Fzn\u00E9ho slo\u017Een\u00ED mastn\u00FDch kyselin v dom\u00E1c\u00ED parenter\u00E1ln\u00ED v\u00FD\u017Eiv\u011B na metabolismus tuk\u016F a ukazatele z\u00E1n\u011Btu" . . . . . .