. "0"^^ . . . "Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma"@en . . "2014-12-31+01:00"^^ . "2015-01-22+01:00"^^ . . " gene expression profiling" . "Molekul\u00E1rn\u00ED charakteristika centrozom\u00E1ln\u00EDch abnormalit a jejich prognostick\u00FD v\u00FDznam pro pacienty s mnoho\u010Detn\u00FDm myelomem" . "2012-04-01+02:00"^^ . . . . "multiple myeloma; gene expression profiling; prognosis; centrosome abnormalities"@en . . "2013-03-26+01:00"^^ . . . . . . "1"^^ . "NT13190" . "multiple myeloma" . "Tento projekt je zam\u011B\u0159en na detailn\u00ED charakterizaci pacient\u016F s mnoho\u010Detn\u00FDm myelomem zalo\u017Eenou na vyu\u017Eit\u00ED genov\u00E9ho expresn\u00EDho profilov\u00E1n\u00ED (GEP) u gen\u016F zodpov\u011Bdn\u00FDch za strukturu a funkci centrozom\u016F se zn\u00E1mou rol\u00ED v procesu kancerogeneze. Anal\u00FDzou expresn\u00EDch profil\u016F t\u011Bchto gen\u016F povede k stratifikaci pacient\u016F do skupin z rozd\u00EDlnou progn\u00F3zou. Hlavn\u00ED c\u00EDle tohoto projektu je n\u00E1sleduj\u00EDc\u00ED: Nal\u00E9zt profil mitotick\u00FDch gen\u016F indikuj\u00EDc\u00EDch p\u0159\u00EDtomnost centrozom\u00E1ln\u00ED abnormalit v plazmatick\u00FDch bu\u0148k\u00E1ch, dle tohoto profilu rozd\u011Blit pacienty do skupin a stanovit klinickou charakteristiku a progn\u00F3zu t\u011Bchto skupin. Prioritou je vytvo\u0159en\u00ED kombinovan\u00E9ho prediktivn\u00EDho & prognostick\u00E9ho modelu zalo\u017Een\u00E9ho na kombinaci molekul\u00E1n\u00EDch profil\u016F a standartn\u00EDch cytogenetick\u00FDch faktor\u016F za \u00FA\u010Delem zv\u00FD\u0161en\u00ED senzitivity a specificity sou\u010D\u00E1sn\u00E9ho vy\u0161et\u0159en\u00ED." . "1"^^ . . " prognosis" . "http://www.isvav.cz/projectDetail.do?rowId=NT13190"^^ . . "This study is focused on detailed characterization of MM patients based on expression profile of genes known to be involved in regulating centrosome duplication and function with known role in oncogenesis. Based on our previous results, we anticipate that expression of these genes can stratify MM patients into groups with divergent prognosis. Main objectives of planned work are: To define mitotic gene pattern, which can be used as a molecular signature of centrosome abnormalities To define groups of patients with similar expression patterns of genes involved in centrosome abnormalities and reveal the clinical relevance of this groups. To establish prognostic sensitivity and value of offered molecular signature as a supplement of existing cytogenetic prognostic factors."@en . . "27"^^ . . "27"^^ .