"1"^^ . " pancreatic cancer" . . "2"^^ . . "1"^^ . "2015-01-22+01:00"^^ . "Statins (inhibitors of HMG-CoA reductase) belong to widely used drugs in human medicine due to their efficient cholesterol lowering effects. Besides this obvious action, statins exert a number of other pleitropic biological effetcs, which contribute to prevention of many diseases, in particular in cardiovascular medicine, transplantology, nefrology, and also possible protective effects in cancer diseases are increasingly discussed. Potential anticancer effects of statins are still subject of discussion, because some clinical studies are controversial. The main reason may the substantial heterogenity of anticancer effects of statins, which, however, differ substantially in their pharmacokinetic and pharmacodynamic properties. Thus, investigation of all these aspects is the major subject of proposed grant project."@en . "1"^^ . . . . "statins" . . . "NT13112" . "2012-04-01+02:00"^^ . "Studies of anticancer effects of statins"@en . . "statins; inhibitors of HMG-CoA reductas; pancreatic cancer; chemoadjuvant therapy"@en . "Statiny (inhibitory HMG-CoA redukt\u00E1zy) pat\u0159\u00ED mezi \u0161iroce pou\u017E\u00EDvan\u00E9 l\u00E9ky v hum\u00E1nn\u00ED medic\u00EDn\u011B pro jejich velmi \u00FA\u010Dinn\u00E9 hypocholesterolemick\u00E9 \u00FA\u010Dinky. Krom\u011B t\u011Bchto hypolipidemick\u00FDch \u00FA\u010Dink\u016F v\u0161ak statiny maj\u00ED \u0159adu dal\u0161\u00EDch pleitropn\u00EDch biologick\u00FDch efekt\u016F, kter\u00E9 hraj\u00ED v\u00FDznamnou roli v prevenci progrese n\u011Bkter\u00FDch onemocn\u011Bn\u00ED, zejm\u00E9na v kardiovaskul\u00E1rn\u00ED medic\u00EDn\u011B, v transplantologii, nefrologii, uva\u017Euje se tak\u00E9 o protektivn\u00EDch \u00FA\u010Dinc\u00EDch u n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED. Potenci\u00E1ln\u00ED protin\u00E1dorov\u00E9 \u00FA\u010Dinky statin\u016F jsou v\u0161ak st\u00E1le p\u0159edm\u011Btem diskuse, nebo\u0165 n\u011Bkter\u00E9 klinick\u00E9 pr\u00E1ce tyto \u00FA\u010Dinky zpochyb\u0148uj\u00ED. Hlavn\u00EDm d\u016Fvodem m\u016F\u017Ee b\u00FDt zna\u010Dn\u00E1 heterogenita protin\u00E1dorov\u00FDch \u00FA\u010Dink\u016F jednotliv\u00FDch statin\u016F, kter\u00E9 se v\u00FDznamn\u011B li\u0161\u00ED sv\u00FDmi farmakokinetick\u00FDmi a farmakodynamick\u00FDmi vlastnostmi. Studium v\u0161ech t\u011Bchto aspekt\u016F je p\u0159edm\u011Btem p\u0159edkl\u00E1dan\u00E9ho grantov\u00E9ho projektu." . " inhibitors of HMG-CoA reductas" . "http://www.isvav.cz/projectDetail.do?rowId=NT13112"^^ . . "2014-03-21+01:00"^^ . "0"^^ . . . "2015-12-31+01:00"^^ . . . . . . "Studium protin\u00E1dorov\u00FDch \u00FA\u010Dink\u016F statin\u016F" . .