"IL-35: a novel cytokine in systemic rheumatic diseases"@en . "2011-06-01+02:00"^^ . . "0"^^ . " idiopathic inflammatory myopat" . . . " autoimmunity" . "2014-12-31+01:00"^^ . . . "IL-35 is a novel cytokine of IL-12 family with unknown functions in human diseases. Since our discovery of increased IL-35 in synovial fluid, its association with disease activity and potential pro-inflammatory role in rheumatoid arthritis (RA) is a new finding; our aims are to analyze serum levels of IL-35 in patients with RA and other systemic rheumatic diseases, and to test correlation between IL-35, disease activity and autoimmune-related manifestations. Special attention is focused on the role of IL-35 in the pathogenesis of chronic inflammation and tissue damage, on the expression of IL-35 in RA synovial tissue samples, and muscle and skin biopsies from patients with idiopathic inflammatory myopathies and systemic sclerosis, respectively. This research should lead to identification of the role of IL-35 in pathogenesis of inflammation in RA and determination whether this pathway is specific for the disease or whether the role for IL-35 is more general in driving chronic inflammatory mechanisms."@en . . "NT12440" . " systemic sclerosis" . "2015-01-22+01:00"^^ . " rheumatoid arthritis" . . . "IL-35 je ned\u00E1vno objeven\u00FD cytokin z rodiny IL-12 s doposud nezn\u00E1mou funkc\u00ED u \u010Dlov\u011Bka. Na\u0161e zji\u0161t\u011Bn\u00ED zv\u00FD\u0161en\u00E9 koncentrace IL-35 v synovi\u00E1ln\u00ED tekutin\u011B, korelace IL-35 s aktivitou nemoci u pacient\u016F s RA a proz\u00E1n\u011Btliv\u00FD mechanismus p\u016Fsoben\u00ED tohoto cytokinu jsou celkem nov\u00E9. Proto je na\u0161\u00EDm c\u00EDlem analyzovat hladiny IL-35 v s\u00E9ru na v\u011Bt\u0161\u00EDm souboru pacient\u016F s RA a u dal\u0161\u00EDch syst\u00E9mov\u00FDch revmatick\u00FDch onemocn\u011Bn\u00EDch, zkoumat vztah IL-35 k aktivit\u011B nemoci a ostatn\u00EDm p\u0159\u00EDznak\u016Fm, kter\u00E9 jsou asociovan\u00E9 s autoimunitn\u00EDmi nemocemi. Zvl\u00E1\u0161tn\u00ED pozornost bude v\u011Bnov\u00E1na studiu role IL-35 v patogenezi chronick\u00E9ho z\u00E1n\u011Btu a n\u00E1sledn\u00E9ho po\u0161kozen\u00ED tk\u00E1n\u011B, jako i expresi IL-35 v revmatoidn\u00ED synovi\u00E1ln\u00ED v\u00FDstelce, ve svalov\u00FDch a ko\u017En\u00EDch biopsi\u00EDch u pacient\u016F s idiopatickou z\u00E1n\u011Btlivou myopati\u00ED a se syst\u00E9movou sklerodermi\u00ED. Tento projekt by m\u011Bl ur\u010Dit roli IL-35 v patogenezi z\u00E1n\u011Btu u RA a objasnit, jestli se jedn\u00E1 o funkci specifickou pro RA nebo obecnou, kter\u00E1 \u0159\u00EDd\u00ED mechanismus chronick\u00E9ho z\u00E1n\u011Btu." . . . "1"^^ . . . "1"^^ . "2013-03-26+01:00"^^ . . "IL-35" . "1"^^ . "IL-35: nov\u00FD cytokin v patogenezi syst\u00E9mov\u00FDch revmatick\u00FDch onemocn\u011Bn\u00ED" . "2"^^ . . . "IL-35; autoimmunity; rheumatoid arthritis; idiopathic inflammatory myopat; systemic sclerosis; disease activity"@en . . . "http://www.isvav.cz/projectDetail.do?rowId=NT12440"^^ .