" ultrasound" . "rheumatoid arthritis; biological response modifier; registry; database; biomarker; ultrasound; remission; monitoring"@en . . "2014-03-21+01:00"^^ . . "2011-06-01+02:00"^^ . " biomarker" . . "2015-12-31+01:00"^^ . " registry" . "NT12437" . "rheumatoid arthritis" . "0"^^ . "Optimalizace v\u00FDsledk\u016F biologick\u00E9 l\u00E9\u010Dby revmatoidn\u00ED artritidy v praxi" . "0"^^ . "1"^^ . . " database" . . . "8"^^ . "8"^^ . . . "Optimalization of biological therapy in Rheumatoid arthritis in clinical practice"@en . . . "http://www.isvav.cz/projectDetail.do?rowId=NT12437"^^ . "Observational studies based on analyses of clinical registries and databases are necessary tools to assess the efficacy and safety of the treatment modalities in real-life clinical practice. In our project we aim to assess the safety and efficacy of biological therapies of the Rheumatoid Arthritis (RA) through analyses of the data of the National Registry for Biological Therapy ATTRA. The complementary project is the analysis of the data recorded in the DYNAMO-RA (DYNAmic MOnitoring of RA) database referring to the prospective cohort of patients with RA followed-up in the Institute of Rheumatology through the protocol-based intensive monitoring program. Part of the DYNAMO-RA project is evaluation of the use of the standardized ultrasound joint score (the German U-7 score) and certain biomarkers (Calprotectin, MMP-3, IL-6) for monitoring of treatment response, and stratification of patients for the single treatment strategies."@en . " biological response modifier" . . . " remission" . . . "2015-01-22+01:00"^^ . . "Nezbytn\u00FDm n\u00E1strojem hodnocen\u00ED bezpe\u010Dnosti a \u00FA\u010Dinnosti l\u00E9\u010Dby v re\u00E1ln\u00E9 klinick\u00E9 praxi jsou observa\u010Dn\u00ED studie zalo\u017Een\u00E9 na anal\u00FDz\u00E1ch klinick\u00FDch registr\u016F a datab\u00E1z\u00ED. V na\u0161em projektu se zam\u011B\u0159ujeme na vyhodnocen\u00ED bezpe\u010Dnosti a \u00FA\u010Dinnosti biologick\u00E9 l\u00E9\u010Dby revmatoidn\u00ED artritidy (RA) anal\u00FDzou dat z n\u00E1rodn\u00EDho registru biologick\u00E9 l\u00E9\u010Dby ATTRA. Komplement\u00E1rn\u00EDm projektem je anal\u00FDza prospektivn\u00ED kohorty pacient\u016F s RA sledovan\u00FDch v Revmatologick\u00E9m \u00FAstavu pomoc\u00ED protokolem \u0159\u00EDzen\u00E9 monitorace v r\u00E1mci v\u00FDzkumn\u00E9 datab\u00E1ze DYNAMO-RA (DYNAmick\u00E1 MOnitorace-RA). Sou\u010D\u00E1st\u00ED projektu je zhodnocen\u00ED p\u0159\u00EDnosu ultrazvukov\u00E9ho sledov\u00E1n\u00ED pomoc\u00ED standardizovan\u00E9ho n\u00E1stroje (German US-7 score), validizace \u010Desk\u00E9 verze multidimension\u00E1ln\u00EDho dotazn\u00EDku zdravotn\u00EDho stavu (MDHAQ) a posouzen\u00ED p\u0159\u00EDnosu n\u011Bkter\u00FDch perspektivn\u00EDch biomarker\u016F (Calprotectin, MMP-3, IL-6) pro monitoraci l\u00E9\u010Debn\u00E9 odpov\u011Bdi a stratifikaci pacient\u016F pro jednotliv\u00E9 l\u00E9\u010Debn\u00E9 strategie." . . .