. . "2015-01-22+01:00"^^ . "dendritic cells" . . . " ovaria cancer" . . . . . "http://www.isvav.cz/projectDetail.do?rowId=NT12402"^^ . . "0"^^ . "2014-03-21+01:00"^^ . . "Dendritic cell based cancer immunotherapy of ovarian cancer Phase I/II clinical trial"@en . "dendritic cells; immunotherapy; ovaria cancer; clinical trial phase I-II"@en . . . . " immunotherapy" . "2015-12-31+01:00"^^ . . "1"^^ . "2011-06-01+02:00"^^ . . "1"^^ . "Na \u00DAstavu imunologie byla vyvinuta individu\u00E1ln\u00ED vakc\u00EDna na b\u00E1zi dendritick\u00FDch bun\u011Bk schopn\u00E1 specificky aktivovat protin\u00E1dorov\u00E9 imunitn\u00ED mechanismy. C\u00EDlem projektu je klinick\u00E1 studie u pacientek s karcinomem ovaria ve st\u00E1diu III-IV dle FIGO (International Federation of Gynecology and Obstetrics) klasifikace. Bude vyhodnocena bezpe\u010Dnost aplikace vakc\u00EDn, schopnost indukce protin\u00E1dorov\u00E9 imunitn\u00ED reakce a klinick\u00E1 odpov\u011B\u010F. Projekt odpov\u00EDd\u00E1 priorit\u00E1m v\u00FDzkumu MZ\u010CR v oblasti ovlivn\u011Bn\u00ED rozvoje n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED manipulac\u00ED imunitn\u00EDho syst\u00E9mu." . "NT12402" . "F\u00E1ze I/II klinick\u00E9 studie imunoterapie ovari\u00E1ln\u00EDho karcinomu pomoc\u00ED vakcinace dendritick\u00FDmi bu\u0148kami" . . "2"^^ . "2"^^ . . "We developed a dendritic cell-based vaccine for cancer immunotherapy. In this project, we plan to run a Phase I/II clinical trial in patients in the stage III-IV of ovarian cancer according the FIGO (International Federation of Gynecology and Obstetrics) classification. Primary endpoint will be the evaluation of vaccine safety. We will also evaluate the capacity to induce tumor specific immune response and objective clinical responses. This proposal is in accordance with the priority in the oncology section of the Ministry of Health program:Targeting of tumors by the modulation of the immune system. We expect to develop a novel treatment modality that would be incorporated into current protocols and that would improve the prognosis of patients with ovarian cancer."@en .