. . . "0"^^ . " prognostic factors" . . "1"^^ . " active-protein profiles" . " protein arrays" . "In the research project we will investigate CML heterogeneity leading to different disease course and treatment responses in individual patients. We will concentrate on the study of CML heterogeneity at level of proteins \u2013 the executive molecules of cell processes. We will follow up differences in active-protein profiles in patients with different responses to tyrosine kinase inhibitors using new technique of protein arrays and other protein analyses. The activity of signaling pathways will be followed up by specific inhibitors. The aim of the study is to find new prognostic markers, new potential treatment targets and to contribute to the improvement of individual therapy."@en . . . "3"^^ . " response to therapy" . "0"^^ . "CML heterogeneity" . "3"^^ . "2015-01-22+01:00"^^ . . . . "Heterogeneity of active-protein profiles in chronic myeloid leukemia and the disease prognosis"@en . "http://www.isvav.cz/projectDetail.do?rowId=NT12392"^^ . "CML heterogeneity; response to therapy; resistance; active-protein profiles; protein arrays; prognostic factors, therapeuti"@en . . . . "2014-12-31+01:00"^^ . "2013-03-26+01:00"^^ . " resistance" . . . "Projekt se bude zab\u00FDvat studiem heterogenity CML vedouc\u00ED k r\u016Fzn\u00E9mu pr\u016Fb\u011Bhu onemocn\u011Bn\u00ED a r\u016Fzn\u00FDm odpov\u011Bd\u00EDm na l\u00E9\u010Dbu. Zam\u011B\u0159\u00EDme se na studium heterogenity na \u00FArovni v\u00FDkonn\u00FDch molekul bun\u011B\u010Dn\u00FDch proces\u016F, tj. protein\u016F. Budeme sledovat rozd\u00EDly v profilech aktivn\u00EDch protein\u016F u pacient\u016F s rozd\u00EDlnou odpov\u011Bd\u00ED na l\u00E9\u010Dbu tyrozinkin\u00E1zov\u00FDmi inhibitory. Budeme vyu\u017E\u00EDvat nejmodern\u011Bj\u0161\u00ED techniku proteinov\u00FDch array\u00ED i dal\u0161\u00ED proteinov\u00E9 anal\u00FDzy. D\u00E1le budeme sledovat vliv inhibitor\u016F sign\u00E1ln\u00EDch drah na bun\u011B\u010Dn\u00E9 procesy. C\u00EDlem je nalezen\u00ED prognostick\u00FDch marker\u016F onemocn\u011Bn\u00ED v diagn\u00F3ze i pr\u016Fb\u011Bhu onemocn\u011Bn\u00ED, p\u0159\u00EDpadn\u011B nov\u00FDch terapeutick\u00FDch c\u00EDl\u016F a v\u00FDsledn\u00E9 zlep\u0161en\u00ED individu\u00E1ln\u00ED l\u00E9\u010Dby pacient\u016F." . "NT12392" . "2011-06-01+02:00"^^ . . . "Studium heterogenity chronick\u00E9 myeloidn\u00ED leukemie na \u00FArovni profil\u016F aktivn\u00EDch protein\u016F - vyu\u017Eit\u00ED v progn\u00F3ze onemocn\u011Bn\u00ED" . .