"Hormon\u00E1ln\u00ED ukazatele jako prediktory v\u00FDvoje ment\u00E1ln\u00EDch zm\u011Bn u pacient\u016F s hydrocefalem" . . . " hormones" . . . . "Selected hormonal and other biochemical parameters in cerebrospinal fluid and serum, along with clinical status will be followed in patients with hydrocephalus treated neurosurgically by sucking off and subsequent channelling an excessive fluid into abdominal cavity. Taking advantage of non-invasive sampling after introduction of shunt and of the aformentioned analyses, we will attempt to find out, why in the most patients after initial improvement the dementia is developed, most frequently of Alzheimer\u00B4s type. Following our previous experience enabling us to distinguish Alzheimer\u00B4s disease from vascular dementia on the base of chosen laboratory parameters, we are going to establish a predictive mathematical model which would contribute to an early disclosure, why such a fatal reversion occurs in these patients."@en . "Hydrocephalus" . "Hydrocephalus; neurosurgery; cerebrospinal fluid; dementia; hormones; neurosteroids"@en . . "2014-12-31+01:00"^^ . " cerebrospinal fluid" . . . " dementia" . . "Hormonal predictors for development of mental disorders in patients with hydrocephalus"@en . . "P\u0159ebyte\u010Dn\u00FD mozkom\u00ED\u0161n\u00ED mok (CSF) je odv\u00E1d\u011Bn neurochirurgicky zaveden\u00EDm dren\u00E1\u017En\u00EDho syst\u00E9mu. Odstran\u011Bn\u00EDm p\u0159ebyte\u010Dn\u00E9ho CSF se normalizuje intrakrani\u00E1ln\u00ED tlak a pacient se dost\u00E1v\u00E1 do subjektivn\u011B dobr\u00E9ho stavu. Odvod CSF se prov\u00E1d\u00ED bu\u010F n\u00E1razov\u011B p\u0159i akutn\u00EDm stavu, nebo kontinu\u00E1ln\u011B zaveden\u00EDm tzv. shuntu, kter\u00FD odv\u00E1d\u00ED p\u0159ebyte\u010Dnou tekutinu nej\u010Dast\u011Bji do dutiny b\u0159i\u0161n\u00ED. V takto z\u00EDskan\u00E9m CSF a v s\u00E9ru budeme analyzovat jak klinick\u00E9 ukazatele, tak vybran\u00E9 biochemick\u00E9 a hormon\u00E1ln\u00ED parametry. Na z\u00E1klad\u011B t\u011Bchto anal\u00FDz se pokus\u00EDme zjistit d\u016Fvod rozvoje ment\u00E1ln\u00EDch poruch u t\u011Bchto pacient\u016F, kter\u00E9 vznikaj\u00ED v relativn\u011B kr\u00E1tk\u00E9m \u010Dasov\u00E9m \u00FAseku od operace a prvotn\u00EDho v\u00FDrazn\u00E9ho zlep\u0161en\u00ED stavu. Na z\u00E1klad\u011B p\u0159ede\u0161l\u00FDch zku\u0161enost\u00ED s rozli\u0161en\u00EDm Alzheimerovy demence od demence vaskul\u00E1rn\u00ED se pokus\u00EDme pomoc\u00ED vytipovan\u00FDch laboratorn\u00EDch parametr\u016F vypracovat matematick\u00FD predik\u010Dn\u00ED model, kter\u00FD by p\u0159isp\u011Bl k v\u010Dasn\u00E9mu odhalen\u00ED tohoto fat\u00E1ln\u00EDho zvratu u pacient\u016F trp\u00EDc\u00EDch hydrocefalem." . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NT12349"^^ . "2011-06-01+02:00"^^ . "1"^^ . "1"^^ . . "2015-01-22+01:00"^^ . " neurosurgery" . "2013-03-26+01:00"^^ . . . "1"^^ . . "NT12349" . . . . "0"^^ .