. " exosomes" . . "2015-01-22+01:00"^^ . . . "0"^^ . . "Circulating microvesicles (microparticles and exosomes) for diagnosis of gynecological malignancies"@en . . "3"^^ . " microvesicles" . "3"^^ . "Reliable biomarkers are needed to improve diagnosis and therapy of gynecological cancer. The aim of the project is to identify molecular characteristics of plasma circulating ovarian cancer and endometrial cancer specific microvesicles. These microvesicles carry proteins and miRNA that would be useful as specific tumor markers. To identify cancer specific biomarkers we propose to combine molecular analysis of circulating microvesicles, cancer cells and tissues. To determine the kinetics and specificity of identified cancer biomarkers we will use advanced model of human carcinogenesis - immunodeficient mice engrafted with human tumors."@en . "1"^^ . "Pro zlep\u0161en\u00ED diagn\u00F3zy gynekologick\u00FDch malignit je nezbytn\u00E9 odhalit nov\u00E9 a spolehliv\u00E9 biomarkery. C\u00EDlem tohoto projektu je podrobn\u00E1 molekul\u00E1rn\u00ED charakterizace cirkuluj\u00EDc\u00EDch mikrovezikul\u016F p\u0159\u00EDtomn\u00FDch v plazm\u011B pacientek s karcinomem ovaria \u010Di endometria. Tyto mikrovezikuly bun\u011B\u010Dn\u00E9ho p\u016Fvodu nesou proteiny a miRNA \u2013 molekuly, kter\u00E9 by mohly slou\u017Eit jako n\u00E1dorov\u011B specifick\u00E9 markery. Abychom tyto potenci\u00E1ln\u00ED biomarkery identifikovali, vyu\u017Eijeme proteomickou a miRNA anal\u00FDzu. K stanoven\u00ED kinetiky a specificity identifikovan\u00FDch n\u00E1drov\u00FDch biomarker\u016F pou\u017Eijeme xenotransplanta\u010Dn\u00ED model \u2013 imunodeficient\u00ED my\u0161i nesouc\u00ED lidsk\u00E9 n\u00E1dory." . " endometrial cancer" . . "1"^^ . . "2015-12-31+01:00"^^ . " ovarian cancer" . . "cancer" . "NT12248" . . . "2011-06-01+02:00"^^ . " microparticles" . "cancer; ovarian cancer; endometrial cancer; microvesicles; exosomes; microparticles; cancer biomarkers; xenotransplantation"@en . . . . "Potenci\u00E1l cirkuluj\u00EDc\u00EDch mikropartikul\u00ED a exosom\u016F pro diagnostiku gynekologick\u00FDch malignit" . . . "2014-03-21+01:00"^^ . " cancer biomarkers" . "http://www.isvav.cz/projectDetail.do?rowId=NT12248"^^ . . .