. . . "Na souboru v\u00EDce ne\u017E 4000 nemocn\u00FDch s lymfomy bude v r\u00E1mci Lymfomov\u00E9ho projektu Kooperativn\u00ED lymfomov\u00E9 skupiny provedena anal\u00FDza klinick\u00FDch a biologick\u00FDch (na \u00FArovni exprese gen\u016F a protein\u016F) prognostick\u00FDch faktor\u016F, v\u00FDvoje l\u00E9\u010Dby, srovn\u00E1n\u00ED v\u00FDsledk\u016F c\u00EDlen\u00E9 a konven\u010Dn\u00ED l\u00E9\u010Dby i se zam\u011B\u0159en\u00EDm na vybran\u00E9 skupiny (star\u0161\u00ED nemocn\u00ED). Nemocn\u00ED jsou za\u0159azov\u00E1ni prospektivn\u011B, data budou dopln\u011Bna a u vybran\u00FDch podskupin budou provedeny i dal\u0161\u00ED biologick\u00E9 studie. V\u00FDsledkem bude popis v\u00FDvoje l\u00E9\u010Dby od roku 1999 do roku 2012, srovn\u00E1n\u00ED jednotliv\u00FDch podskupin, kter\u00E9 nejv\u00EDce profituj\u00ED z c\u00EDlen\u00E9 terapie. Projekt je zam\u011B\u0159en i na anal\u00FDzu nemocn\u00FDch s relapsem, srovn\u00E1n\u00ED prognostick\u00FDch faktor\u016F p\u0159i diagn\u00F3ze a v relapsu, zp\u016Fsoby l\u00E9\u010Dby v\u010Detn\u011B c\u00EDlen\u00E9 a osud nemocn\u00FDch i v z\u00E1vislosti na typu l\u00E9\u010Dby pou\u017Eit\u00E9 v induk\u010Dn\u00ED f\u00E1zi p\u0159i diagn\u00F3ze. V\u00FDsledky budou srovn\u00E1ny se zahrani\u010Dn\u00EDmi daty, publikov\u00E1ny v mezin\u00E1rodn\u00EDch \u010Dasopisech a budou vypracov\u00E1ny doporu\u010Den\u00E9 postupy jako z\u00E1klad standard\u016F." . " targeted therapy" . "2011-06-01+02:00"^^ . . . " prognostic factors" . . "The aim of the project is to characterize the outcome of patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in the Czech Republic during the period 1999-2012 and to analyze factors influencing this outcome. Study will be performed on Czech Lymphoma Study Group registry cohort of approx. 4000 patients. The following factors will be analyzed \u2013 the access of older patients to targeted therapy and the outcome of these pts., the comparison younger and older patients, the impact of prognostic factors, clinical and biological on outcome of pts treated without and with targeted therapy. Discordant bone marrow involvement, GCB and nonGCB profile, will be studied. The relapses characteristic as well as the FL transformation will be analyzed. The ultimate goal of the project is to describe \u201Creal life\u201D lymphoma management, to answer some conflicted questions regarding the prognostic factors and targeted therapy and finally to improve the quality of the care on lymphoma patients."@en . "2014-03-21+01:00"^^ . "2"^^ . . . "2"^^ . . "1"^^ . "diffuse large B-cell lymphoma" . "diffuse large B-cell lymphoma; follicular lymhoma; targeted therapy; prognostic factors; relapse; treatment"@en . . "2015-01-22+01:00"^^ . "Diffuse large B-cell and follicular lymphoma - the analysis of prognostic factors and therapeutic strategies on patient\u00B4s outcome; Lymphoma Project in the Czech Republic."@en . . "Dif\u00FAzn\u00ED velkobun\u011B\u010Dn\u00FD a folikul\u00E1rn\u00ED lymfom - anal\u00FDza vlivu prognostick\u00FDch faktor\u016F a l\u00E9\u010Debn\u00FDch postup\u016F na osud nemocn\u00FDch; lymfomov\u00FD projekt \u010Cesk\u00E9 republiky." . . . "0"^^ . "NT12193" . " follicular lymhoma" . . " relapse" . . "2015-12-31+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NT12193"^^ . . "8"^^ .